Table 4 Recommendations concerning pharmocological treatments in PD patients with delirium
From: Cognitive disorders in advanced Parkinson’s disease: challenges in the diagnosis of delirium
Indication/symptoms | To be avoided | To be prefered |
|---|---|---|
Infections (pneumonia, cystitis …) | Fluorchinolons, Nitrofurantoin | ß-lactam antibiotics, makrolids |
pain | Opioids | Ibuprofen, Paracetamol, Metamizol |
Insomnia | Benzodiazepines, z-substances, H1-antihistamines | Melatonin, Quetiapine, Mirtazapine |
Incontinence | Oxybutinin, Solifenacin, Tolterodine | Mirabegron, Trospiumchloride |
Antidepressants | Tricyclic antidepressants | SSRI, Mirtazapine |
PD symptoms | Anticholinergics Amantadine Dopaminagonists MAO-B-inhibitors Opicapone (withdrawal in this order) | L-dopa, Entacapone |
Neuroleptics | Typical neuroleptics | Quetiapine |
Antidementives | Avoid acute withdrawal or escalation of dosage | |