Table 1 Overview of previously reported cases of brivaracetam during pregnancy and childbirth in women with epilepsy
Authors | Cases | BRV/d | Further ASM/d | Conc. of BRV during pregnancy | Conc. of BRV in umbilical cord | Conc. of BRV postpartum) | Serum ratio (infant/mother) | Newborn malformation |
|---|---|---|---|---|---|---|---|---|
Paolini et al. [15] | 3 | P1*: 100 mg P2: 150 mg P3: 200 mg | None None P3: LTG 450 mg | – – – | – – – | – – – | – – – | Congenital dermal melanocytosis and ankyloglossia Infantile hemangioma on thumb and back None |
Landmark et al. [11] | 2 | P 1: 150 mg P2: 200 mg | P1: none P2: PER 8 mg, LCM 400 mg | P1: 3,8 umol/l **(0.81 mg/l) P2: 6,6 umol/l **(1.40 mg/l) | Twin 1: 4,1 umol/l **(0.87 mg/l) Twin 2: 4,2 umol/l **(0.89 mg/l) P2: 1, 2umol/l **(0.25 mg/l) | P1: 4,4 umol/l **(0.93 mg/l) P2: 6,1 umol/l **(1.29 mg/l) | 1.08 1.11 0.18 | None None None |
Navarro [14] | 1 | 200 mg | none | – | – | – | – | None |