Table 2 Blood serum concentrations of brivaracetam (BRV) and topiramate (TPM) before, during and after pregnancy
BRV concentration (200 mg/d) Reference range: 0.5–0.9 mg/l* (mg/l) | TPM concentration (200 mg/d) Reference range: 2.0–10.0 mg/l (mg/l) | |
|---|---|---|
Before pregnancy | 3.31 | 4.7 |
Week of pregnancy: 17 | 2.91 | 4.7 |
Week of pregnancy: 21 | 4.53 | 6.5 |
Week of pregnancy: 25 | 4.21 | 5.7 |
Week of pregnancy: 30 | 2.48 | 4.1 |
Week of pregnancy: 33 + | 2.57 | 4.5 |
Week of pregnancy: 37 | 3.6 | 4.6 |
After pregnancy (1 month) | 3.32 | 7.3 |
After pregnancy (8 month) | 3.87 | 6.2 |
Umbilical cord blood | 1.97 | 3.0 |