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Table 3 Results of meta-analyses for PFO closure in cryptogenic stroke

From: Cryptogenic stroke and patent foramen ovale (abridged and translated version)

Author Studies N Endpoint   95% CI P
Abo Salem et al. [12] 5 3627 Stroke RR 0.48 0.3–0.7 0.001
De Rosa et al. [13] 4 3216 Stroke and TIA RD −0.029 −0.050 - -0.007 0.008
Ntaios et al. [11] 5 3627 Stroke OR 0.43 0.21–0.90 NI
Shah et al. [14] 4 2892 Stroke RD −0.032 −0.050 - -0.014 0.011
Saver et al. [24] 6 3560 Stroke HR 0.30 0.13–0.68 0.004
Ahmad et al. [15] 5 3440 Stroke HR 0.32 0.13–0.82 0.018
  1. RR relative risk; CI confidence interval, RD Risk Difference OR Odds Ratio, NI not indicated