Fig. 2

a FMRI results from a gambling task in young healthy participants. Axial slices show greater activation for win compared to loss trials in the ventral striatum and midbrain after placebo and pramipexole. A single dose of pramipexole (0.5 mg) resulted in a marked attenuation of reward based activations. After data presented in Riba et al. [74]. b FMRI results from a monetary incentive delay task. Shown are core regions of the reward processing network for the contrast “expectation of reward > expectation of no-reward”. Please note that PD patients on dopamine agonist treatment show a marked attenuation of activation compared to healthy controls and PD patients off medication (unpublished data from Ye and Münte obtained from 17 PD patients and 17 matched control participants). c Nucleus accumbens connectivity during reward expectation in a monetary incentive delay task. Regions functionally connected with the NAcc during reward expectation under placebo and pramipexole. Arrows indicate the frontal cortex (blue) and the insular cortex (green). The scheme at the bottom presents the connectivity patterns under placebo and pramipexole. The dopamine agonist therapy results in a shift of connectivity (less connectivity between NAcc and frontal cortex, greater connectivity between NAcc and insular cortex)