Localized | upper and/or lower respiratory tract +/− |
Early systemic | without impaired organ function or life-threatening disease + |
Generalized disease | with impairment of renal or other organ function, Creatinine < 500 μmol/l + |
Serious | renal or vital organ failure, Creatinine ≥500 μmol/l + |
Refractory | progressive disease which does not respond to standard therapy + |