Table 4 Dosage Details for Remission-inducing Immunosuppressive Therapy in Initial Manifestations which impair Organ Function or are Life-threatening, or in Major Recurrences of an AAV [24, 56, 64]
| Prednisolone | 1 mg/kg (maximal 80 mg) daily, reduction to 7.5–10 mg daily within 12 weeks |
| RTX | 375 mg/m2 i.v. weekly for 4 weeks |
| CYC-Bolus Therapy | 15 mg/kg (maximal 1200 mg) i.v., the first 3 boli at 14-day intervals, the following3 boli (and others as indicated) at 21-day intervals |
| Oral CYC Therapy | 2 mg/kg (maximal 200 mg daily) |