Skip to main content

Advertisement

Table 1 Exclusion criteria

From: The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial

• History of hypersensitivity to corticosteroids
• Systemic corticosteroid treatment within the last six months or at present time (> 20 mg p.o. or generally intravenous intake)
• Two fixed dilated pupils
• Pre-event score mRS more than two or Barthel Index less than 95
• Pregnancy
• Breast feeding women
• Recent history of active tuberculosis or systemic fungal infection
• Recent head trauma/neurosurgery/peptic ulcer disease
• Life expectancy less than three years
• Other serious illness that confound treatment assessment
• Simultaneous participation in another clinical trial
• Previous participation in another clinical trial in the last 30 days
• Previous participation in this clinical trial
• Women of childbearing potential who are not using a highly effective birth control method
• Acute viral infections other than HSVE (herpes zoster, poliomyelitis, chickenpox)
• Hepatitis B surface Antigen-positive chronic active hepatitis
• Approximately eight weeks before to two weeks after prophylactic vaccination
• Lymphadenitis following Bacille Calmette Guérin vaccination.