From: General principles and escalation options of immunotherapy in autoantibody-associated disorders of the CNS
1000 mg/day for 5 days, if needed with oral tapering
0.4 g/kg/day over 5 days
Plasma exchange or immunoadsorbtion
+Tumor therapy in paraneoplastic cases as soon as possible!
Initially 500–2000 mg IV, followed by 250–1000 mg every 6 months or depending on B-cell repopulation*
Induction with 750–1000 mg/m2 of BSA (e.g. 300–350 mg/m2/d over 3 days), followed by 500–750 mg/m2 of BSA every 4 weeks#
Further long-term immunotherapies§
1 g/kg body weight every 4–6 weeks IV, alternatively subcutaneously in equivalent dose (home setting)
Oral immunosuppressive drugs alone or in combination with prednisolone
Reserve therapies in refractory disease course
8 mg/kg every 4 weeks
1–2 cycles with 1.3 mg/m2/cycle s.c., administered on days 1, 4, 8, 11, followed by other long-term therapy.