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Table 13 Summary of relevant CSF findings in neuropsychiatric lupus

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

Parameter

Diagnostic LP

Follow-up LP (under immunosuppressive treatment)

Remarks

Cell count

1-400/μL

in 30 to 44% of patients

  

Cell type

Lymphocytes, monocytes

  

Albumin ratio

< 8 × 10−3: 60%

8-25 × 10− 3: 40%

  

Quantitative IgG-, IgA-, IgM-synthesis

IgG > 0%: 30%

IgA > 0%: 13%

IgM > 0%: 17%

  

OCB

Type 2 or 3: 30%

Change to type 1 or 4 possible

 

MRZ reaction

AI ≥1.5

Measles: 30%

Rubella: 30%

Zoster: 40%

 

Intrathecal dsDNA antibodies in 20%