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Table 13 Summary of relevant CSF findings in neuropsychiatric lupus

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

ParameterDiagnostic LPFollow-up LP (under immunosuppressive treatment)Remarks
Cell count1-400/μL
in 30 to 44% of patients
  
Cell typeLymphocytes, monocytes  
Albumin ratio< 8 × 10−3: 60%
8-25 × 10− 3: 40%
  
Quantitative IgG-, IgA-, IgM-synthesisIgG > 0%: 30%
IgA > 0%: 13%
IgM > 0%: 17%
  
OCBType 2 or 3: 30%Change to type 1 or 4 possible 
MRZ reaction
AI ≥1.5
Measles: 30%
Rubella: 30%
Zoster: 40%
 Intrathecal dsDNA antibodies in 20%