Table 20 Immunological recognition of lymphoma cells in CSF
From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)
B-NHL | T-NHL |
|---|---|
Predominance of B cells | Strong deviation of CD4/CD8-ratio, High percentage of CD4+CD8+ cells |
Light chain restriction (Monoclonality) Lack of light chains Isolated IgM production | Loss of normally expressed antigens (e.g., CD7, CD5) |
Co-expression of immature or aberrant antigens on or in B cells (e.g. CD 34, CD 10, CD 30, TdT, CD5) | Co-expression of immature or aberrant antigens on or in T cells (e.g.CD34, CD 10, CD 30, TdT, CD1a) |