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Table 20 Immunological recognition of lymphoma cells in CSF

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

B-NHLT-NHL
Predominance of B cellsStrong deviation of CD4/CD8-ratio,
High percentage of CD4+CD8+ cells
Light chain restriction (Monoclonality)
Lack of light chains
Isolated IgM production
Loss of normally expressed antigens (e.g., CD7, CD5)
Co-expression of immature or aberrant antigens on or in B cells (e.g. CD 34, CD 10, CD 30, TdT, CD5)Co-expression of immature or aberrant antigens on or in T cells (e.g.CD34, CD 10, CD 30, TdT, CD1a)