Fig. 2
From: Glymphatic system, AQP4, and their implications in Alzheimer’s disease
Glymphatic System in Healthy vs AD condition. In healthy condition, CSF flows across highly polarized AQP4 molecules at astrocyte end-feet, mixing with ISF, which allows the clearance of Aβ. However, in pathological situations, such as in AD, there is a loss of AQP4 polarization, resulting in restricted CSF-ISF flow, contributing to Aβ accumulation