| |
DMG
|
Placebo
|
|---|
|
Baseline (n = 20)
|
12 months (n = 17)
|
Baseline (n = 10)
|
12 months (n = 9)
|
|---|
|
Age (years)
|
54.9 ± 5.7
| |
52.1 ± 5.9
| |
|
Sex (M/F)
|
6/14
| |
1/9
| |
|
SPMS (M/F)
|
4/10
| |
0/8
| |
|
PPMS (M/F)
|
2/4
| |
1/1
| |
|
Weight (kg)
|
75.8 ± 16.3
| |
75.6 ± 21.3
| |
|
Height (cm)
|
167.6 ± 10.1
| |
166.4 ± 7.1
| |
|
Disease duration (years)
|
13.8 ± 9.3
| |
18.8 ± 10.0
| |
|
Study variables
|
|
EDSS (score)
|
4.6 ± 2.0 (5.3)
|
4.5 ± 2.0 (4.5)
|
5.2 ± 1.5 (6.0)
|
5.3 ± 1.7 (6.0)
|
|
FIS-D (score)
|
85.8 ± 26.8 (86.5)
|
76.0 ± 35.0 (86.0)
|
73.3 ± 25.7 (73.5)
|
81.6 ± 21.5 (89.0)
|
|
PASAT (score)
|
40.6 ± 8.8 (39.0)
|
41.4 ± 12.0 (36.0)
|
35.6 ± 7.0 (34.0)
|
44.2 ± 9.7 (42.0)
|
|
Gait velocity (km/h)
|
2.5 ± 1.1
|
2.5 ± 1.2
|
2.6 ± 0.7
|
2.6 ± 0.8
|
|
Stride length (m)
|
0.50 ± 0.1
|
0.52 ± 0.2
|
0.49 ± 0.1
|
0.55 ± 0.2
|
|
Stride variability (%)
|
4.2 ± 2.7
|
4.4 ± 4.5
|
12.9 ± 22.9
|
11.7 ± 17.1
|
|
6 min Walking Test (m)
|
259.9 ± 141.8
|
267.2 ± 135.6
|
268.6 ± 80.5
|
277.3 ± 84.5
|
|
Knee angle stance (left/2 + right/2)(°)
|
16.3 ± 4.9
|
16.4 ± 4.4
|
17.8 ± 7.5
|
17.5 ± 6.1
|
|
Knee angle swing (left/2 + right/2)(°)
|
48.8 ± 10.5
|
49.1 ± 9.2
|
47.8 ± 7.7
|
49.7 ± 6.7
|
- SPMS secondary progressive MS, PPMS primary progressive MS, EDSS Expanded Disability Status Scale, FIS-D Fatigue Impact Scale, PASAT Paced Auditory Serial Addition Test, mean ± sd () = median
