Fig. 1

Correlation between health-related quality of life and other factors in TSC. Health-related quality of life (HRQoL) in adult individuals with tuberous sclerosis complex (TSC), as assessed by the Quality of Life in Epilepsy Inventory-31 items (QOLIE-31) overall score was significantly correlated with A) the number of affected organ systems, B) the grade of disability, and C) the overall Liverpool Adverse Events Profile (LAEP) score, which measures therapy-related adverse events. D: HRQoL in adults with TSC was also significantly correlated with the perceived burden of illness, which was calculated as an index of 20 possible TSC-associated problems (possible range of 0–4 for each item)