Quality of life and its predictors in adults with tuberous sclerosis complex (TSC): a multicentre cohort study from Germany

Table 5 Multiple linear regression analyses evaluating potential TSC-related predictors of health-related quality of life (QOLIE-31 overall score)

	Regression coefficient B	*SE B*	beta	p-value	Semi-partial correlation	Tolerance
LAEP total score	−0.906	0.143	−0.548	< 0.001	− 0.644 \| f² 0.709 – large effect	0.757
Active epilepsy (yes/no)	−12.608	2.810	−0.358	< 0.001	−0.511 \| f² 0.353 – large effect	0.885
Neuropsychiatric symptoms (yes/no)	−10.401	3.312	−0.293	0.003	−0.384 \| f² 0.173 – medium effect	0.644
Number of affected organs	1.234	1.066	0.102	0.252	0.152	0.726
Employment (yes/no)	2.457	2.951	0.070	0.409	0.110	0.800
Grade of disability (≤80/> 80)	−1.081	3.390	−0.030	0.751	−0.042	0.615
	Adjusted R² = 0.65; F = 20.15, Sig. F. (p < 0.001)

Variables are ordered according to the standardised B (beta) values, in descending order
LAEP Liverpool Adverse Events Profile, SE standard error. Effect sizes were calculated from the semi-partial correlation as r²_part / (1 − r²_part). Tolerance was used as a measure of predictor multicollinearity, with tolerance values above a threshold of 0.25 indicating no collinearity

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