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Table 5 Multiple linear regression analyses evaluating potential TSC-related predictors of health-related quality of life (QOLIE-31 overall score)

From: Quality of life and its predictors in adults with tuberous sclerosis complex (TSC): a multicentre cohort study from Germany

  Regression coefficient B SE B beta p-value Semi-partial correlation Tolerance
LAEP total score −0.906 0.143 −0.548 < 0.001 − 0.644 | f2 0.709 – large effect 0.757
Active epilepsy (yes/no) −12.608 2.810 −0.358 < 0.001 −0.511 | f2 0.353 – large effect 0.885
Neuropsychiatric symptoms (yes/no) −10.401 3.312 −0.293 0.003 −0.384 | f2 0.173 – medium effect 0.644
Number of affected organs 1.234 1.066 0.102 0.252 0.152 0.726
Employment (yes/no) 2.457 2.951 0.070 0.409 0.110 0.800
Grade of disability (≤80/> 80) −1.081 3.390 −0.030 0.751 −0.042 0.615
  Adjusted R2 = 0.65; F = 20.15, Sig. F. (p < 0.001)
  1. Variables are ordered according to the standardised B (beta) values, in descending order
  2. LAEP Liverpool Adverse Events Profile, SE standard error. Effect sizes were calculated from the semi-partial correlation as r2part / (1 − r2part). Tolerance was used as a measure of predictor multicollinearity, with tolerance values above a threshold of 0.25 indicating no collinearity