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Table 5 Multiple linear regression analyses evaluating potential TSC-related predictors of health-related quality of life (QOLIE-31 overall score)

From: Quality of life and its predictors in adults with tuberous sclerosis complex (TSC): a multicentre cohort study from Germany

 

Regression coefficient B

SE B

beta

p-value

Semi-partial correlation

Tolerance

LAEP total score

−0.906

0.143

−0.548

< 0.001

− 0.644 | f2 0.709 – large effect

0.757

Active epilepsy (yes/no)

−12.608

2.810

−0.358

< 0.001

−0.511 | f2 0.353 – large effect

0.885

Neuropsychiatric symptoms (yes/no)

−10.401

3.312

−0.293

0.003

−0.384 | f2 0.173 – medium effect

0.644

Number of affected organs

1.234

1.066

0.102

0.252

0.152

0.726

Employment (yes/no)

2.457

2.951

0.070

0.409

0.110

0.800

Grade of disability (≤80/> 80)

−1.081

3.390

−0.030

0.751

−0.042

0.615

 

Adjusted R2 = 0.65; F = 20.15, Sig. F. (p < 0.001)

  1. Variables are ordered according to the standardised B (beta) values, in descending order
  2. LAEP Liverpool Adverse Events Profile, SE standard error. Effect sizes were calculated from the semi-partial correlation as r2part / (1 − r2part). Tolerance was used as a measure of predictor multicollinearity, with tolerance values above a threshold of 0.25 indicating no collinearity