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Table 1 CSF SARS-CoV-2-specific IgG antibodies against the spike (S1) and the nucleocapsid (NCP) protein and neurotransmitter levels in the index patient compared to control subjects

From: Persistent cognitive impairment associated with cerebrospinal fluid anti-SARS-CoV-2 antibodies six months after mild COVID-19

  Index patient Control subjects P value
CSF SARS-CoV-2 antibodies
 IgG anti-S1, 1:2 0.450 0.044 +/−  0.009 (n = 2) 0.017
 IgG anti-S1, 1:5 0.190 0.039 +/−  0.009 (n = 2) 0.048
 IgG anti-NCP, 1:2 0.150 0.036 +/−  0.015 (n = 2) 0.102
 IgG anti-NCP, 1:5 0.073 0.024 +/− 0.007 (n = 2) 0.114
CSF neurotransmitter levels
 Glutamate (μM) 3.70 4.53 +/− 0.82 (n = 3) 0.546
 GABA (μM) 0.30 0.32 +/− 0.02 (n = 3) 0.434
 Glutamine (μM) 604 634 +/−  82 (n = 3) 0.820
  1. Mean +/− standard deviation is shown. Differences were assessed using student’s t-test. p < 0.05 was considered significant
  2. GABA Gamma-aminobutyric acid