Table 1 CSF SARS-CoV-2-specific IgG antibodies against the spike (S1) and the nucleocapsid (NCP) protein and neurotransmitter levels in the index patient compared to control subjects
Index patient | Control subjects | P value | |
|---|---|---|---|
CSF SARS-CoV-2 antibodies | |||
IgG anti-S1, 1:2 | 0.450 | 0.044 +/− 0.009 (n = 2) | 0.017 |
IgG anti-S1, 1:5 | 0.190 | 0.039 +/− 0.009 (n = 2) | 0.048 |
IgG anti-NCP, 1:2 | 0.150 | 0.036 +/− 0.015 (n = 2) | 0.102 |
IgG anti-NCP, 1:5 | 0.073 | 0.024 +/− 0.007 (n = 2) | 0.114 |
CSF neurotransmitter levels | |||
Glutamate (μM) | 3.70 | 4.53 +/− 0.82 (n = 3) | 0.546 |
GABA (μM) | 0.30 | 0.32 +/− 0.02 (n = 3) | 0.434 |
Glutamine (μM) | 604 | 634 +/− 82 (n = 3) | 0.820 |