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Fig. 1 | Neurological Research and Practice

Fig. 1

From: Controversy on the treatment of multiple sclerosis and related disorders: positional statement of the expert panel in charge of the 2021 DGN Guideline on diagnosis and treatment of multiple sclerosis, neuromyelitis optica spectrum diseases and MOG-IgG-associated disorders

Fig. 1

Consensus was reached that category 1 drugs should be used as first-line treatment in DMD-naive patients unless the disease course is considered probably highly active (see A25). Efficacy category 2 and 3 DMDs should be used if category 1 drugs have failed to control the disease. However, apart from this well-known escalation approach, category 2 and 3 agents should also be offered to DMD-naive patients whose disease course is considered probably highly active from the beginning (see A29). The choice of category 1 to 3 thus follows both a step-in and a step-up approach. (OLU, off-label use)

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Neurological Research and Practice

ISSN: 2524-3489

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