Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review

Table 2 Overview of selected clinical and diagnostic findings in the presented case and literature review

	Case	NMDA + ITPR1 + GFAP (i.e. [1])	ITPR1 (i.e. [1])	GFAP (i.e. [6])	MOG (i.e. [8, 9])
Clinical symptoms
Subacute onset	+	+	+	+	+
Prior infection	+ (vaginal herpes)	+		+	+
Meningism	+			+
Confusion	+	+		+
Para/Tetraparesis	+	+	+	+
Sensory loss	+	+	+	+
Ataxia	+		+	+
Nystagmus	+		+
Seizures	+	+	+	+
Autonomic symptoms	+ (neccessary pace maker)		+	+
Vision deficits				+	+
Neuropathy			+
Areflexia	+		+
Diagnostic Examinations
Signs of meningitis in MRI	+			+
T2w lesions in cerebral MRI	+ (esp. parieto-occipital)	+ (esp. temporo-cerebellar)		+ (esp. periventricular white matter)	+ (esp. deep grey matter involvement)
Spinal MRI	+ (spinal cord swelling, edema)	+ (long myelitis)	+ (myelitis)	+ (myelitis)	+ (myelitis)
Tumor association	(+) (borderline tumor of left ovary)	-	41% tumor association (no borderline known)	36% tumor association (no borderline known)	Usually no tumor association

ISSN: 2524-3489