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Table 3 Factors associated with in-hospital mortality: total study cohort

From: Does diabetes mellitus affect the safety profile of valproic acid for the treatment of status epilepticus? A retrospective cohort study

Characteristics

In-hospital mortality

Survival of hospital

p-value

Patients

N = 65

N = 343

 

Demographics

Age

79 (71–87)

72 (60–80)

 < 0.001

Sex m (male) f (female)

m 21 (32%) f 44 (68%)

m 167 (49%) f 176 (51%)

0.015

Premorbid mRS

4 (2 –4)

3 (1–4)

0.004

Comorbidities

Charlson Comorbidity Index

4 (3–6)

3 (1–4)

 < 0.001

Diabetes mellitus

26 (40%)

107 (31%)

0.165

Insulin-dependent diabetes mellitus

7 (11%)

48 (14%)

0.511

Status epilepticus (SE)

STESS ≥ 3

60 (92%)

212 (62%)

 < 0.001

Etiology of SE

Potentially fatal etiology

44 (68%)

82 (24%)

 < 0.001

Treatment with VPA

VPA single infusion*

2 (3%)

40 (12%)

0.037

VPA repeated or continuous infusion

63 (97%)

303 (88%)

0.037

In-hospital complications

Need for mechanical ventilation

37 (57%)

143 (42%)

0.023

Episodes of hypoglycemia*

3 (5%)

9 (3%)

0.416

Bleeding with intervention*

2 (3%)

18 (5%)

0.753

  1. Metric variables are described with median and interquartile range, categorial variables in number and percentage. Continuous variables were compared using Mann–Whitney U test. Proportions were compared using Pearson´s Chi2 test or Fisher´s exact test (*). Statistically significant values (p < 0.05) are expressed in bold
  2. mRS modified Rankin scale; STESS status epilepticus severity score; SE status epilepticus; VPA valproic acid