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  1. Immunological alterations associated with increased susceptibility to infection are an essential aspect of stroke pathophysiology. Several immunological functions of adipose tissue are altered by obesity and a...

    Authors: Johanna Ruhnau, Christin Heuer, Carl Witt, Sonya Ceesay, Juliane Schulze, Stefan Gross, Maria Waize, Marie-Luise Kromrey, Jens-Peter Kühn, Sönke Langner, Uwe Grunwald, Barbara M. Bröker, Astrid Petersmann, Antje Steveling, Alexander Dressel and Antje Vogelgesang
    Citation: Neurological Research and Practice 2023 5:42
    Content type: Research article Published on:

  2. Over the last century, significant milestones have been achieved in managing critical illness and diagnosing and treating neurological diseases. Building upon these milestones, the field of neurocritical care ...

    Authors: Rainer Kollmar and Michael De Georgia
    Citation: Neurological Research and Practice 2023 5:43
    Content type: Review Published on:

  3. Mobile gait sensors represent a compelling tool to objectify the severity of symptoms in patients with idiopathic Parkinson’s disease (iPD), but also to determine the therapeutic benefit of interventions. In p...

    Authors: F. Mügge, U. Kleinholdermann, A. Heun, M. Ollenschläger, J. Hannink and D. J. Pedrosa
    Citation: Neurological Research and Practice 2023 5:33
    Content type: Research article Published on:

  4. Assessment of quality of life (QoL) has become an important indicator for chronic neurological diseases. While these conditions often limit personal independence and autonomy, they are also associated with tre...

    Authors: Kai Siebenbrodt, Laurent M. Willems, Felix von Podewils, Peter Michael Mross, Michael Strüber, Lisa Langenbruch, Laura Bierhansl, Iris Gorny, Juliane Schulz, Bernadette Gaida, Nadine Conradi, Annika Süß, Felix Rosenow and Adam Strzelczyk
    Citation: Neurological Research and Practice 2023 5:41
    Content type: Research article Published on:

  5. The AT(N) research framework for Alzheimer's disease (AD) remains unclear on how to best deal with borderline cases. Our aim was to characterise patients with suspected AD with a borderline Aß1-42/Aß1-40 ratio i...

    Authors: Dariia Yosypyshyn, Domantė Kučikienė, Inez Ramakers, Jörg B. Schulz, Kathrin Reetz and Ana Sofia Costa
    Citation: Neurological Research and Practice 2023 5:40
    Content type: Research article Published on:

  6. The avoidance of hematoma expansion is the most important therapeutic goal during acute care of patients with intracerebral hemorrhage. Hematoma expansion occurs in up to 20–40% of patients and leads to poorer...

    Authors: David Haupenthal, Stefan Schwab and Joji B. Kuramatsu
    Citation: Neurological Research and Practice 2023 5:36
    Content type: Review Published on:

  7. Movement disorders emergencies describe acute-onset neurological conditions in which a delay of recognition and treatment may cause severe morbidity and mortality of patients. Hyperkinetic movement disorders i...

    Authors: Anna Sauerbier, Alexandra Gronostay and Haidar S. Dafsari
    Citation: Neurological Research and Practice 2023 5:35
    Content type: Standard operating procedure Published on:

  8. Stroke is a leading cause of mortality and disability worldwide and its occurrence is expected to increase in the future. Blood biomarkers have proven their usefulness in identification and monitoring of the d...

    Authors: Lino Braadt, Markus Naumann, Dennis Freuer, Timo Schmitz, Jakob Linseisen and Michael Ertl
    Citation: Neurological Research and Practice 2023 5:31
    Content type: Research article Published on:

  9. Multiple studies have focused on medical and pharmacological treatments and outcome predictors of patients with status epilepticus (SE). However, a sufficient understanding of recurrent episodes of SE is lacki...

    Authors: Kristina Bauer, Felix Rosenow, Susanne Knake, Laurent M. Willems, Leena Kämppi and Adam Strzelczyk
    Citation: Neurological Research and Practice 2023 5:34
    Content type: Research article Published on:

  10. Post-stroke infections may cause sepsis, which is associated with poor clinical outcome. Sepsis is defined by life-threatening organ dysfunction that can be identified using the Sequential Organ Failure Assess...

    Authors: Sebastian Stösser, Lisa Kleusch, Alina Schenk, Matthias Schmid and Gabor C. Petzold
    Citation: Neurological Research and Practice 2023 5:32
    Content type: Research article Published on:

  11. Patients with ischemic stroke and atrial fibrillation (AF) are at particularly high risk for recurrent stroke and cardiovascular events. Early rhythm control has been shown to be superior to usual care for the...

    Authors: Märit Jensen, Rustam Al-Shahi Salman, G. Andre Ng, H. Bart van der Worp, Peter Loh, Bruce C. V. Campbell, Jonathan M. Kalman, Michael D. Hill, Luciano A. Sposato, Jason G. Andrade, Andreas Metzner, Paulus Kirchhof and Götz Thomalla
    Citation: Neurological Research and Practice 2023 5:29
    Content type: Research article Published on:

  12. Alzheimer´s disease is considered a neurodegenerative disease and is diagnosed by exclusion, while the detection of specific cerebrospinal fluid (CSF) biomarkers, namely amyloid-beta (Aβ) peptides Aβ1–42 (Aß42...

    Authors: Franz Felix Konen, Hannah Benedictine Maier, Alexandra Neyazi, Stefan Bleich, Konstantin Neumann and Thomas Skripuletz
    Citation: Neurological Research and Practice 2023 5:30
    Content type: Research article Published on:

  14. Cerebral Amyloid Angiopathy-related inflammation (CAA-ri) is a distinct but rare subset of CAA. The greater availability of high resolution Magnetic Resonance Imaging (MRI) has currently allowed the increasing...

    Authors: Aikaterini Theodorou, Athanasios Tsibonakis, Ioannis S Pateras, Georgia Kaloudi, Eleni Bakola, Maria Chondrogianni, Elissavet Andreadou, Ioannis G Panayiotides and Georgios Tsivgoulis
    Citation: Neurological Research and Practice 2023 5:28
    Content type: Letter to the editor Published on:

  15. In 2021, the Deutsche Gesellschaft für Neurology published a new guideline on diagnosis and therapy of motor neuron disorders. Motor neuron disorders affect upper motor neurons in the primary motor cortex and/...

    Authors: Susanne Petri, Torsten Grehl, Julian Grosskreutz, Martin Hecht, Andreas Hermann, Sarah Jesse, Paul Lingor, Wolfgang Löscher, André Maier, Benedikt Schoser, Marcus Weber and Albert C. Ludolph
    Citation: Neurological Research and Practice 2023 5:25
    Content type: Guidelines Published on:

  16. Myasthenia gravis (MG) is a rare neuromuscular disorder. Symptoms can range from ptosis only to life threatening myasthenic crisis. Thymectomy is recommended for anti-acetylcholine receptor-antibody positive p...

    Authors: Hruy Menghesha, Michael Schroeter, Christopher Nelke, Tobias Ruck, Georg Schlachtenberger, Clara Welskop, Amina Camo, Matthias Heldwein, Gerardus Bennink, Thorsten Wahlers, Servet Bölükbas, Fabian Doerr and Khosro Hekmat
    Citation: Neurological Research and Practice 2023 5:24
    Content type: Research article Published on:

  17. Here we report on a patient with Parkinson's Disease and camptocormia due to Myofibrillar Myopathy Type 3. By leading the reader through the clinical reasoning process and highlighting the respective red flags...

    Authors: Jan Niklas Petry-Schmelzer, Angela Abicht, Michael T. Barbe and Gilbert Wunderlich
    Citation: Neurological Research and Practice 2023 5:26
    Content type: Letter to the editor Published on:

    The Letter to the editor to this article has been published in Neurological Research and Practice 2023 5:45

  18. Patients with Parkinson’s Disease (PD) require an all-encompassing and individualized care including pharmacological as well as non-pharmacological treatment approaches, such as physical therapy, occupational ...

    Authors: Katharina Achtert, Tessa Huchtemann, Maria Altendorf, Linda Kerkemeyer, Malte Haring, Carina Lummer, Lena Frenz, Theresa Becking, Jonas Friedmann, Philip Mildner, Katharina Schwarze, Lars Steinhaus, Volker Amelung and Tobias Warnecke
    Citation: Neurological Research and Practice 2023 5:23
    Content type: Clinical trial protocol Published on:

  19. About 25% of all ischaemic strokes are related to cardio-embolism, most often due to atrial fibrillation (AF). Little is known about the extent and standardization of routine cardiac diagnostic work-up at cert...

    Authors: Manuel C. Olma, Serdar Tütüncü, Ulrike Grittner, Claudia Kunze, Muhammad Jawad-Ul-Qamar, Paulus Kirchhof, Joachim Röther, Götz Thomalla, Roland Veltkamp, Ulrich Laufs, Darius G. Nabavi, Peter U. Heuschmann, Matthias Endres and Karl Georg Haeusler
    Citation: Neurological Research and Practice 2023 5:21
    Content type: Research article Published on:

  20. Large vessel occlusion (LVO) is a severe condition that carries a high risk of morbidity and mortality, underscoring the importance of effective prevention strategies. This retrospective study aimed to analyze...

    Authors: Konstantin Kohlhase, Jan Hendrik Schäfer, Lisa Marie Tako, Laurent M. Willems, Elke Hattingen, Ferdinand O. Bohmann, Christian Grefkes, Felix Rosenow and Adam Strzelczyk
    Citation: Neurological Research and Practice 2023 5:22
    Content type: Research article Published on:

  21. Discontinuing anti-seizure medication (ASM) should be considered in persons with epilepsy with long-term seizure freedom. Clinicians should also pursue ASM withdrawal in persons with one-time seizures without ...

    Authors: Laurien K. L. Dhaenens-Meyer, Elisabeth Schriewer, Yvonne G. Weber and Stefan Wolking
    Citation: Neurological Research and Practice 2023 5:20
    Content type: Research article Published on:

    The Letter to the editor to this article has been published in Neurological Research and Practice 2023 5:47

  22. Groundbreaking study results since 2014 have dramatically changed the therapeutic options in acute therapy for severe ischemic stroke caused by large vessel occlusion (LVO). The scientifically proven advances ...

    Authors: Julian Bösel, Gordian J. Hubert, Jessica Jesser, Markus A. Möhlenbruch and Peter A. Ringleb
    Citation: Neurological Research and Practice 2023 5:19
    Content type: Standard operating procedure Published on:

  23. Motor impairments are the objectively most striking sequelae after stroke, but non-motor consequences represent a high burden for stroke survivors as well. Depression is reported in one third of patients, the ...

    Authors: Frederike A. Straeten, Stephanie van Zyl, Bastian Maus, Jochen Bauer, Heiner Raum, Catharina C. Gross, Sabine Bruchmann, Nils C. Landmeyer, Cornelius Faber, Jens Minnerup and Antje Schmidt-Pogoda
    Citation: Neurological Research and Practice 2023 5:18
    Content type: Clinical trial protocol Published on:

  24. Unpredictable vegetative deteriorations made the treatment of patients with acute COVID-19 on intensive care unit particularly challenging during the first waves of the pandemic. Clinical correlates of dysauto...

    Authors: Marcel Seungsu Woo, Christina Mayer, Marlene Fischer, Stefan Kluge, Kevin Roedl, Christian Gerloff, Patrick Czorlich, Götz Thomalla, Julian Schulze zur Wiesch and Nils Schweingruber
    Citation: Neurological Research and Practice 2023 5:17
    Content type: Research article Published on:

  26. In 2022 the DGN (Deutsche Gesellschaft für Neurologie) published an updated Transient Global Amnesia (TGA) guideline. TGA is characterized by a sudden onset of retrograde and anterograde amnesia for a period o...

    Authors: Dirk Sander, Thorsten Bartsch, Florian Connolly, Christian Enzinger, Urs Fischer, Nils Nellessen, Holger Poppert, Kristina Szabo and Helge Topka
    Citation: Neurological Research and Practice 2023 5:15
    Content type: Guidelines Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:64

  27. Epidural electrical epinal cord stimulation (ESCS) is an established therapeutic option in various chronic pain conditions. In the last decade, proof-of-concept studies have demonstrated that ESCS in combinati...

    Authors: Antonia Luz, Rüdiger Rupp, Rezvan Ahmadi and Norbert Weidner
    Citation: Neurological Research and Practice 2023 5:14
    Content type: Review Published on:

  28. Infective endocarditis (IE) is a serious condition with a high mortality, represents a rare cause of stroke and an increased risk of intracranial hemorrhage. In this single center study, we characterize stroke...

    Authors: L. Nitsch, O. Shirvani Samani, M. Silaschi, M. Schafigh, S. Zimmer, G. C. Petzold, C. Kindler and F. J. Bode
    Citation: Neurological Research and Practice 2023 5:13
    Content type: Research article Published on:

  29. The relationship between presenting blood pressure in acute ischemic stroke patients and outcome is complex. Several studies have demonstrated a U-shaped curve with worse outcomes when blood pressure is high o...

    Authors: Michael De Georgia, Theodore Bowen, K. Rose Duncan and Alex Bou Chebl
    Citation: Neurological Research and Practice 2023 5:12
    Content type: Review Published on:

  33. Treatment of relapsed or refractory primary CNS lymphoma (r/r PCNSL) is difficult, particularly in patients not eligible for high dose chemotherapy with autologous stem cell transplantation (HDC-ASCT). No stan...

    Authors: Sabine Seidel, Thomas Kowalski, Verena Nilius-Eliliwi, Roland Schroers and Uwe Schlegel
    Citation: Neurological Research and Practice 2023 5:8
    Content type: Research article Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:16

  34. Post-stroke dysphagia (PSD) is common and can lead to serious complications. Pharyngeal sensory impairment is assumed to contribute to PSD. The aim of this study was to investigate the relationship between PSD...

    Authors: Bendix Labeit, Anne Jung, Sigrid Ahring, Stephan Oelenberg, Paul Muhle, Malte Roderigo, Fiona Wenninger, Jonas von Itter, Inga Claus, Tobias Warnecke, Rainer Dziewas and Sonja Suntrup-Krueger
    Citation: Neurological Research and Practice 2023 5:7
    Content type: Research article Published on:

  35. Regional deprivation has been shown to be an influential factor in stroke incidence risk. However, there is a paucity of knowledge on regional differences in stroke incidence and mortality in Germany.

    Authors: Matthias Hans Belau, Heiko Becher, Maya Riefflin, Dirk Bartig, Lars Schwettmann, Christopher Jan Schwarzbach and Armin Grau
    Citation: Neurological Research and Practice 2023 5:6
    Content type: Research article Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:16

  36. Spontaneous intracerebral hemorrhage (ICH) is a devastating type of stroke with a huge impact on patients and families. Expanded use of oral anticoagulants and ageing population might contribute to an epidemio...

    Authors: Ludovica De Rosa, Renzo Manara, Francesca Vodret, Caterina Kulyk, Florian Montano, Alessio Pieroni, Federica Viaro, Maria Luisa Zedde, Rosa Napoletano, Mario Ermani and Claudio Baracchini
    Citation: Neurological Research and Practice 2023 5:5
    Content type: Research article Published on:

  37. Ulnar mononeuropathy at the elbow is the second most frequent neuropathy in humans. Diagnosis is based on clinical and electrophysiological criteria and, more recently, also on ultrasound. Cross-sectional ult...

    Authors: José Manuel Pardal-Fernández, Inmaculada Diaz-Maroto, Tomás Segura and Carlos de Cabo
    Citation: Neurological Research and Practice 2023 5:4
    Content type: Research article Published on:

    The Letter to the editor to this article has been published in Neurological Research and Practice 2023 5:27

  38. Echocardiography is highly relevant in patients with ischemic stroke or TIA. Utilization of routine echocardiographic examinations [transthoracic (TTE) or transesophageal (TEE)] on stroke units remains however...

    Authors: Timolaos Rizos, Ekkehart Jenetzky, Darius Günther Nabavi, Karl Georg Haeusler, Rolf Wachter, Martin Ossenbrink, Peter Arthur Ringleb and Otto Busse
    Citation: Neurological Research and Practice 2023 5:3
    Content type: Research Article Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:16

  39. The aim of this study was to investigate the prognostic role of hematoma characteristics and hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (ICH).

    Authors: Renzo Manara, Ludovica De Rosa, Francesca Vodret, Caterina Kulyk, Renato Pennella, Eleonora Contrino, Giacomo Cester, Francesco Causin, Alessio Pieroni, Federica Viaro, Maria Luisa Zedde, Rosario Pascarella, Rosa Napoletano and Claudio Baracchini
    Citation: Neurological Research and Practice 2023 5:2
    Content type: Research Article Published on:

  40. We review key design elements of positive randomized controlled trials (RCTs) in acute ischemic stroke (AIS) treatment and summarize their main characteristics.

    Authors: L. Yperzeele, A. Shoamanesh, Y. V. Venugopalan, S. Chapman, M. V. Mazya, M. Charalambous, V. Caso, W. Hacke, P. M. Bath and I. Koltsov
    Citation: Neurological Research and Practice 2023 5:1
    Content type: Review Published on:

  41. The medical care of patients with myositis is a great challenge in clinical practice. This is due to the rarity of these disease, the complexity of diagnosis and management as well as the lack of systematic an...

    Authors: Marc Pawlitzki, Laura Acar, Lars Masanneck, Alice Willison, Liesa Regner-Nelke, Christopher Nelke, Helmut L’hoest, Ursula Marschall, Jens Schmidt, Sven G. Meuth and Tobias Ruck
    Citation: Neurological Research and Practice 2022 4:62
    Content type: Research Article Published on:

  42. Safety and efficacy data on intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) in case of known left ventricular thrombus (LVT) are lacking. We present the case of a 35-year-old male with disabling...

    Authors: Sofia Kitmeridou, Dimitrios Tsiptsios, Dimos Tsalkidis, Evlampia A. Psatha, Ioannis Iliopoulos, Nikolaos Aggelousis and Konstantinos Vadikolias
    Citation: Neurological Research and Practice 2022 4:61
    Content type: Letter to the editor Published on:

    The Letter to the editor to this article has been published in Neurological Research and Practice 2023 5:10

  43. The ALS Functional Rating Scale in its revised version (ALSFRS-R) is a disease-specific severity score that reflects motor impairment and functional deterioration in people with amyotrophic lateral sclerosis (...

    Authors: André Maier, Matthias Boentert, Peter Reilich, Simon Witzel, Susanne Petri, Julian Großkreutz, Moritz Metelmann, Paul Lingor, Isabell Cordts, Johannes Dorst, Daniel Zeller, René Günther, Tim Hagenacker, Torsten Grehl, Susanne Spittel, Joachim Schuster…
    Citation: Neurological Research and Practice 2022 4:60
    Content type: Research Article Published on:

  44. Post-stroke depression (PSD) is an important and frequent non-motor complication after a stroke. As valid prediction of PSD occurrence is still not possible, the unselective use of preventive therapy in stroke...

    Authors: Daniel Richter, Andreas Ebert, Lisa Mazul-Wach, Quirin Ruland, Jeyanthan Charles-James, Ralf Gold, Georgios Tsivgoulis, Georg Juckel and Christos Krogias
    Citation: Neurological Research and Practice 2022 4:59
    Content type: Clinical Trial Protocol Published on:

  45. Patients with a left (LHS) or right hemispheric stroke (RHS) differ in terms of clinical symptoms due to lateralization of specific cortical functions. Studies on functional outcome after stroke and endovascul...

    Authors: Milani Deb-Chatterji, Fabian Flottmann, Lukas Meyer, Caspar Brekenfeld, Jens Fiehler, Christian Gerloff and Götz Thomalla
    Citation: Neurological Research and Practice 2022 4:58
    Content type: Research article Published on:

  47. Misdiagnosis of seizure-like events (SLE) in emergency situations is common. Here, we evaluate whether a single, video-based lesson highlighting distinguishing semiological features can improve the diagnostic ...

    Authors: Wenke Grönheit, Vanessa Behrens, Tatjana Liakina, Christoph Kellinghaus, Soheyl Noachtar, Stoyan Popkirov, Tim Wehner, Eva Brammen and Jörg Wellmer
    Citation: Neurological Research and Practice 2022 4:56
    Content type: Research article Published on:

  48. Therapeutic options targeting inflammation in multiple sclerosis (MS) have evolved rapidly for relapsing–remitting MS, whereas few therapies are available for progressive forms of MS, in particular secondary p...

    Authors: Liesa Regner-Nelke, Marc Pawlitzki, Alice Willison, Leoni Rolfes, Sinem-Hilal Oezalp, Christopher Nelke, Tristan Kölsche, Melanie Korsen, Matthias Grothe, Sergiu Groppa, Felix Luessi, Sinah Engel, Gereon Nelles, Eckhard Bonmann, Holger Roick, Anke Friedrich…
    Citation: Neurological Research and Practice 2022 4:55
    Content type: Research article Published on:

  49. Seizure Related 6 Homolog Like 2 (SEZ6L2) protein has been shown to have implications in neuronal and especially motor function development. In oncology, overexpression of SEZ6L2 serves as a negative prognosti...

    Authors: Annika Kather, Florian Holtbernd, Robert Brunkhorst, Dimah Hasan, Robert Markewitz, Klaus-Peter Wandinger, Martin Wiesmann, Jörg B. Schulz and Simone C. Tauber
    Citation: Neurological Research and Practice 2022 4:54
    Content type: Review Published on:

  50. Recent studies have indicated that long-term neurological sequelae after COVID-19 are not accompanied by an increase of canonical biomarkers of central nervous system injury in blood, but subgroup stratificati...

    Authors: Laura de Boni, Alexandru Odainic, Natalie Gancarczyk, Luisa Kaluza, Christian P. Strassburg, Xenia A. K. Kersting, Joseph M. Johnson, Ullrich Wüllner, Susanne V. Schmidt, Jacob Nattermann and Gabor C. Petzold
    Citation: Neurological Research and Practice 2022 4:53
    Content type: Letter to the editor Published on:
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