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Table 2 Main results for healthy subjects and de novo Parkinson patients (PD) in group comparison

From: Conditioned pain modulation in drug-naïve patients with de novo Parkinson’s disease

Parameters
(mean, standard deviation, [Min-Max])
Healthy subjects
(n = 17)
De novo Parkinson patients
(n = 17)
Group comparison Healthy subjects vs. De novo
(p-value)
Age 61.7+/−  9.8 [45–75] 61.9 +/−  9.8 [42–75] t(32) = − 0.070, p = 0.945
Gender 10 male, 7 female 10 male, 7 female
PANDA Score 24.6 +/− SD 3.0 [17–29] 21.1 +/− 4.0 [15–29] t(32) = 2.848, p= 0.008
HADS subscale depression 1.3 +/− 1.3 [0–4] 3.5 +/− 2.5 [0–9] U = 227.5, z = 2.901, p= 0.003
HADS subscale anxiety 2.2 +/− 2.1 [0–6] 4.5 +/− 4.3 [0–14] U = 187.5, z = 1.498, p = 0.140
Mean stimulation temperature 48.2 +/− 0.8 [47.0–49.5] 47.9 +/−  0.9 [45.5–49.0] U = 80.5, z = − 0.739, p = 0.478
Mean pain intensity
Block 1 [VAS 0–100]
55.9 +/−  8.8 [38.7–67.0] 60.8 +/−  12.1 [37.8–86.8] t(32) = − 1.380, p = 0.177
Cold pain rating Block 2 [VAS 0–100] 74.8 +/−  18.3 [29–97] 58.7+/−  27.4 [14–96] t(27.874) = 2.023, p = 0.053*
Expectation
Rating Day 1 [− 1 to + 1]
− 0.2 +/−  0.4 [− 0.8–0.5] 0.1 +/−  0.4 [− 0.7–0.9] t(32) = −2.609, p= 0.014
CPM Magnitude 3.1 +/− 6.4 [− 5.1–13.3] 1.7 +/−  6.7 [− 9.8–13.9] t(32) = 0.611, p = 0.545
  1. Significant results are marked in bold
  2. Abbreviations: UPDRS Unified Parkinson’s disease rating scale, HADS Hospital anxiety and depression score, PANDA Parkinson neuropsychometric dementia assessment
  3. *= P-value and degree of freedom corrected for unequal variances