Table 2 Main results for healthy subjects and de novo Parkinson patients (PD) in group comparison
From: Conditioned pain modulation in drug-naïve patients with de novo Parkinson’s disease
Parameters (mean, standard deviation, [Min-Max]) | Healthy subjects (n = 17) | De novo Parkinson patients (n = 17) | Group comparison Healthy subjects vs. De novo (p-value) |
|---|---|---|---|
Age | 61.7+/− 9.8 [45–75] | 61.9 +/− 9.8 [42–75] | t(32) = − 0.070, p = 0.945 |
Gender | 10 male, 7 female | 10 male, 7 female | – |
PANDA Score | 24.6 +/− SD 3.0 [17–29] | 21.1 +/− 4.0 [15–29] | t(32) = 2.848, p = 0.008 |
HADS subscale depression | 1.3 +/− 1.3 [0–4] | 3.5 +/− 2.5 [0–9] | U = 227.5, z = 2.901, p = 0.003 |
HADS subscale anxiety | 2.2 +/− 2.1 [0–6] | 4.5 +/− 4.3 [0–14] | U = 187.5, z = 1.498, p = 0.140 |
Mean stimulation temperature | 48.2 +/− 0.8 [47.0–49.5] | 47.9 +/− 0.9 [45.5–49.0] | U = 80.5, z = − 0.739, p = 0.478 |
Mean pain intensity Block 1 [VAS 0–100] | 55.9 +/− 8.8 [38.7–67.0] | 60.8 +/− 12.1 [37.8–86.8] | t(32) = − 1.380, p = 0.177 |
Cold pain rating Block 2 [VAS 0–100] | 74.8 +/− 18.3 [29–97] | 58.7+/− 27.4 [14–96] | t(27.874) = 2.023, p = 0.053* |
Expectation Rating Day 1 [− 1 to + 1] | − 0.2 +/− 0.4 [− 0.8–0.5] | 0.1 +/− 0.4 [− 0.7–0.9] | t(32) = −2.609, p = 0.014 |
CPM Magnitude | 3.1 +/− 6.4 [− 5.1–13.3] | 1.7 +/− 6.7 [− 9.8–13.9] | t(32) = 0.611, p = 0.545 |