Articles

The special role of CXCL13 in Lyme neuroborreliosis: a case report

The diagnosis of chronic lyme neuroborreliosis can be a challenge even for experienced neurologists. The clinical picture may be multifaceted, including polyradiculitis to cranial nerve palsies, meningitis, en...

Authors: Deborah K. Erhart, Vera Bracknies, Susanne Lutz-Schuhbauer, Sonja Wigand and Hayrettin Tumani

Neurological management and work-up of neurotoxicity associated with CAR T cell therapy

Treatment with CD19 chimeric antigen receptor (CAR) T cells is an innovative therapeutic approach for patients with relapsed/refractory diffuse large B cell lymphoma (r/rDLBCL) and B-lineage acute lymphoblasti...

Authors: Nora Möhn, Viktoria Bonda, Lea Grote-Levi, Victoria Panagiota, Tabea Fröhlich, Christian Schultze-Florey, Mike P. Wattjes, Gernot Beutel, Matthias Eder, Sascha David, Sonja Körner, Günter Höglinger, Martin Stangel, Arnold Ganser, Christian Koenecke and Thomas Skripuletz

Therapy development for spinal muscular atrophy: perspectives for muscular dystrophies and neurodegenerative disorders

Major efforts have been made in the last decade to develop and improve therapies for proximal spinal muscular atrophy (SMA). The introduction of Nusinersen/Spinraza™ as an antisense oligonucleotide therapy, On...

Authors: Sibylle Jablonka, Luisa Hennlein and Michael Sendtner

Long-term recovery of upper limb motor function and self-reported health: results from a multicenter observational study 1 year after discharge from rehabilitation

Impaired motor functions after stroke are common and negatively affect patients' activities of daily living and quality of life. In particular, hand motor function is essential for daily activities, but often ...

Authors: Thies Ingwersen, Silke Wolf, Gunnar Birke, Eckhard Schlemm, Christian Bartling, Gabriele Bender, Alfons Meyer, Achim Nolte, Katharina Ottes, Oliver Pade, Martin Peller, Jochen Steinmetz, Christian Gerloff and Götz Thomalla

DIPS (Dystonia Image-based Programming of Stimulation: a prospective, randomized, double-blind crossover trial)

Deep brain stimulation of the internal globus pallidus is an effective treatment for dystonia. However, there is a large variability in clinical outcome with up to 25% non-responders even in highly selected pr...

Authors: Florian Lange, Jonas Roothans, Tim Wichmann, Götz Gelbrich, Christoph Röser, Jens Volkmann and Martin Reich

Impact of the COVID-19 pandemic on emergency admission for patients with stroke: a time series study in Japan

Appropriate treatment of stroke immediately after its onset contributes to the improved chances, while delay in hospitalisation affects stroke severity and fatality. This study aimed to determine the impact of...

Authors: Takuaki Tani, Shinobu Imai and Kiyohide Fushimi

Seizures and epilepsy in patients with ischaemic stroke

With the increased efficacy of stroke treatments, diagnosis and specific treatment needs of patients with post-stroke seizures (PSS) and post-stroke epilepsy have become increasingly important. PSS can complic...

Authors: Johann Philipp Zöllner, Friedhelm C. Schmitt, Felix Rosenow, Konstantin Kohlhase, Alexander Seiler, Adam Strzelczyk and Hermann Stefan

Thromboses of major arteries and ChAdOx1 nCov-19 vaccination

This correspondence discussed on published article on “thromboses of major arteries and ChAdOx1 nCov-19 vaccination”.

Authors: Rujittika Mungmunpuntipantip and Viroj Wiwanitkit

Evidence of extensive cellular immune response after SARS-CoV-2 vaccination in ocrelizumab-treated patients with multiple sclerosis

Patients with multiple sclerosis receiving ocrelizumab-treatment are in desperate need of a protection against SARS-CoV-2 infection.

Authors: Mosche Pompsch, Neslinur Fisenkci, Peter A. Horn, Markus Kraemer and Monika Lindemann

Performance of ENMC and EULAR/ACR classification systems applied to a single tertiary center cohort of dermatomyositis patients

There have been numerous classification systems to diagnose corresponding myositis subtypes and select appropriate therapeutic measures. However, the lack of a broad consensus on diagnostic criteria has led to...

Authors: Jan Zoske, Udo Schneider, Elise Siegert, Felix Kleefeld, Corinna Preuße, Werner Stenzel and Katrin Hahn

A neurologist’s rhombencephalitis after comirnaty vaccination. A change of perspective

Rhombencephalitis is an orphan disease of multiple causes that may manifest with facial palsy, limb ataxia and reduced consciousness. Up to now it is described after COVID-19 infection and in this (personal) c...

Authors: Alexander Walter and Markus Kraemer

Are we creating a new phenotype? Physiological barriers and ethical considerations in the treatment of hereditary transthyretin-amyloidosis

Hereditary transthyretin (TTR) amyloidosis (ATTRv) is an autosomal dominant, systemic disease transmitted by amyloidogenic mutations in the TTR gene. To prevent the otherwise fatal disease course, TTR stabilizers...

Authors: Maike F. Dohrn, Jessica Medina, Karmele R. Olaciregui Dague and Ernst Hund

An updated calculator for determining levodopa-equivalent dose

Calculation of levodopa-equivalent dose in Parkinson’s disease has become common in research, but is also a useful tool in clinical practice, especially when initiating device-aided treatments (deep brain stim...

Authors: D. Nyholm and W. H. Jost

Successful implementation of best medical treatment for patients with asymptomatic carotid artery stenosis within a randomized controlled trial (SPACE-2)

Asymptomatic carotid artery stenosis (ACS) can be treated with carotid endarterectomy (CEA), carotid artery stenting (CAS), or best medical treatment (BMT) only. For all treatment options, optimization of vasc...

Authors: Tilman Reiff, Hans-Henning Eckstein, Ulrich Mansmann, Olav Jansen, Gustav Fraedrich, Harald Mudra, Werner Hacke and Peter Arthur Ringleb

Bilateral non-bifurcating carotid arteries in a patient with recurrent cerebrovascular events

Among congenital anomalies of the carotid artery circulation, the presence of a non-bifurcating carotid artery is extremely rare. Relevant cases with unilateral non-bifurcating carotid artery have scarcely bee...

Authors: Lina Palaiodimou, Georgia Papagiannopoulou, Aikaterini Theodorou, Eleni Bakola, Maria Chondrogianni, Maria-Ioanna Stefanou, Elizabeth Andreadou, Stefanos Lachanis and Georgios Tsivgoulis

Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review

Recently, antibodies against the alpha isoform of the glial-fibrillary-acidic-protein (GFAPα) were identified in a small series of patients with encephalomyelitis. Coexisting autoantibodies (NMDA receptor, GAD...

Authors: Anna Cirkel, Klaus-Peter Wandinger, Claudia Ditz, Jan Leppert, Lars Hanker, Christoph Cirkel, Alexander Neumann, Jan Brocke, Romana Höftberger, Lars Komorowski, Sven Perner, Frank Leypoldt, Tobias Wagner-Altendorf, Thomas F. Münte and Georg Royl

Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination

The ChAdOx1 nCoV-19 adenoviral vector vaccine to prevent contracting Covid-19 caused by infection with SARS-CoV-2 has been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) primarily le...

Authors: Yasemin Goereci, Nina N. Kleineberg, Marie Madlener, Hannah Neuschmelting, Gereon R. Fink, Clemens Warnke and Henning Stetefeld

Index event of cerebral amyloid angiopathy (CAA) determines long-term prognosis and recurrent events (retrospective analysis and clinical follow-up)

The modified Boston criteria (mBC) define the probability for the diagnosis of cerebral amyloid angiopathy (CAA). Its initial clinical presentation differs from asymptomatic cerebral microbleedings (cMBs), acu...

Authors: Andrea Wagner, Christiane Groetsch, Sibylle Wilfling, Karl-Michael Schebesch, Mustafa Kilic, Marjan Nenkov, Christina Wendl, Ralf A. Linker and Felix Schlachetzki

Development and reliability of the histological THROMBEX-classification rule for thrombotic emboli of acute ischemic stroke patients

Thrombus histology has become a potential diagnostic tool for the etiology assessment of patients with ischemic stroke caused by embolic proximal vessel occlusion. We validated a classification rule that diffe...

Authors: Julika Ribbat-Idel, Florian Stellmacher, Florian Jann, Nicolas Kalms, Inke R. König, Marcus Ohlrich, Georg Royl, Stefan Klotz, Thomas Kurz, Andrè Kemmling and Florian C. Roessler

Isolated thalamic stroke – analysis of clinical characteristics and asymmetry of lesion distribution in a retrospective cohort study

More patients with left-hemispheric than right-hemispheric strokes are admitted to hospitals. This is due to the easier recognition of cortical symptoms of the dominant-hemisphere. The thalamus constitutes a “...

Authors: Martin A. Schaller-Paule, Ariane Martinez Oeckel, Jan-Rüdiger Schüre, Fee Keil, Elke Hattingen, Christian Foerch and Maximilian Rauch

Digital concepts in post-stroke care pathways: adding value and minimizing burden

Authors: Christoph Schöbel and Martin Köhrmann

The PostStroke-Manager – combining mobile, digital and sensor-based technology with personal assistance: protocol of the feasibility study

Post stroke management has moved into the focus as it represents the only way to secure acute treatment effects in the long term. Due to individual courses, post stroke management appears rather challenging an...

Authors: Dominik Michalski, Alexander Prost, Till Handel, Max Schreiber, Jean-Baptiste Tylcz, Daniela Geisler, Daniela Urban, Stephanie Schramm, Stefan Lippmann, Jenny Gullnick, Thomas Neumuth, Joseph Classen and Galina Ivanova

Neuroradiological emergency consultations during the first year of the COVID-19 pandemic

Measures taking aim at minimizing the risk of coronavirus transmission and fear of infection may affect decisions to seek care for other medical emergency conditions. The purpose of this analysis was to analyz...

Authors: Johannes A. R. Pfaff, Marcial E. Harlan, Günter Pfaff, Alexander Hubert and Martin Bendszus

Profiles of patients’ self-reported health after acute stroke

We aimed to identify groups of patients with similar health status after stroke, assessed by patient reported outcome measures (PROMs), to improve initial risk stratification.

Authors: D. Leander Rimmele, Theresa Schrage, Lisa Lebherz, Levente Kriston, Christian Gerloff, Martin Härter and Götz Thomalla

Multiple sclerosis is not associated with an increased risk for severe COVID-19: a nationwide retrospective cross-sectional study from Germany

Since the coronavirus disease 2019 (COVID-19) has risen, several risk factors have been identified, predicting a worse outcome. It has been speculated that patients with Multiple sclerosis (MS) have an increas...

Authors: Daniel Richter, Simon Faissner, Dirk Bartig, Lars Tönges, Kerstin Hellwig, Ilya Ayzenberg, Christos Krogias and Ralf Gold

Factors influencing the detection of treatable epileptogenic lesions on MRI. A randomized prospective study

To prospectively analyze factors associated with detecting epileptogenic lesions on MRI within the work-sharing process of neurologists, epileptologists, radiologists and neuroradiologists.

Authors: Tim Wehner, Philippe Weckesser, Steven Schulz, Annika Kowoll, Sebastian Fischer, Jessica Bosch, Leonie Weinhold, Rolf Fimmers, Matthias Schmid and Jörg Wellmer

No consensus about consensus?

Authors: Ludwig Kappos

Controversy on the treatment of multiple sclerosis and related disorders: positional statement of the expert panel in charge of the 2021 DGN Guideline on diagnosis and treatment of multiple sclerosis, neuromyelitis optica spectrum diseases and MOG-IgG-associated disorders

Authors: A. Bayas, A. Berthele, B. Hemmer, C. Warnke and B. Wildemann

Multiple sclerosis therapy consensus group (MSTCG): answers to the discussion questions

Authors: Heinz Wiendl, Ralf Gold and Frauke Zipp

Quality assurance data for regional drip-and-ship strategies- gearing up the transfer process

Stroke patients with large vessel occlusion (LVO) require endovascular therapy (EVT) provided by comprehensive stroke centers (CSC). One strategy to achieve fast stroke symptom ‘onset to treatment’ times (OTT)...

Authors: Erendira G. Boss, Ferdinand O. Bohmann, Björn Misselwitz, Manfred Kaps, Tobias Neumann-Haefelin, Waltraud Pfeilschifter and Natalia Kurka

Neurological manifestations of COVID-19 – an approach to categories of pathology

Various neurological manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported, associated with a broad spectrum of diverse neurological symptoms and synd...

Authors: Yana Leven and Julian Bösel

Simulation-based training improves patient safety climate in acute stroke care (STREAM)

Treatment of acute stroke performed by a multiprofessional, interdisciplinary team is highly time dependent. Interface problems are preprogrammed and pitfalls relevant to patient safety are omnipresent. The Sa...

Authors: Ferdinand O. Bohmann, Joachim Guenther, Katharina Gruber, Tanja Manser, Helmuth Steinmetz and Waltraud Pfeilschifter

Chromium and cobalt intoxication mimicking mitochondriopathy

A 53-year old male with a history of progressive visual impairment, hearing loss, peripheral neuropathy, poorly controlled diabetes mellitus, cardiomyopathy, and weight loss was referred to the rare disease ce...

Authors: Tim W. Rattay, Torsten Kluba and Ludger Schöls

Better be prepared: the spectrum of neuropsychiatric impairment among Libyan war victims transferred to Germany for trauma rehabilitation

The current Libyan civil war has originated many casualties, imposing medical challenges. War injuries are complex, requiring specialized knowledge and interdisciplinary assessment for adequate patient and int...

Authors: Felix Dootz, Otto-Magnus von Stackelberg, Joan Abaya, Christian Jacobi, Christoph Mohs, Eva Maria Craemer, Christoph Rangger, Uta Meyding-Lamadé and Eva Kathrin Lamadé

Quality of life and its predictors in adults with tuberous sclerosis complex (TSC): a multicentre cohort study from Germany

Tuberous sclerosis complex (TSC) is a monogenetic, multisystemic disease characterised by the formation of benign tumours that can affect almost all organs, caused by pathogenic variations in TSC1 or TSC2. In thi...

Authors: Johann Philipp Zöllner, Nadine Conradi, Matthias Sauter, Markus Knuf, Susanne Knake, Gerhard Kurlemann, Thomas Mayer, Christoph Hertzberg, Astrid Bertsche, Ilka Immisch, Karl Martin Klein, Klaus Marquard, Sascha Meyer, Anna H. Noda, Felix von Podewils, Hannah Schäfer…

Persistent cognitive impairment associated with cerebrospinal fluid anti-SARS-CoV-2 antibodies six months after mild COVID-19

Neurological long-term sequelae are increasingly considered an important challenge in the recent COVID-19 pandemic. However, most evidence for neurological symptoms after SARS-CoV-2 infection and central nervo...

Authors: Max Borsche, Dirk Reichel, Anja Fellbrich, Anne S. Lixenfeld, Johann Rahmöller, Eva-Juliane Vollstedt, Bandik Föh, Alexander Balck, Christine Klein, Marc Ehlers and Andreas Moser

Optic disc drusen mimicking Idiopathic Intracranial Hypertension (IIH): rely on ultrasound

Optic nerve ultrasound is an established routine supplementary diagnostic tool for idiopathic intracranial pressure but it can also be helpful in avoiding misdiagnoses. We describe a case of an obese 15- year-...

Authors: Eleni Bakola, Dimitrios Alonistiotis, Chryssa Arvaniti, Stavroula Salakou, Niki Nana, Aikaterini Foska, Vasiliki Kotsali-Peteinelli, Konstantinos Voumvourakis and Georgios Tsivgoulis

Letter to the Editor: Analysis of stroke patient migration for mechanical thrombectomy and changes in neurointerventional center size in Germany

To analyse nationwide changes in neurointerventional center size of all German hospitals performing mechanical thrombectomy (MT) in stroke patients from 2016 to 2019. Furthermore, we assessed cross-district pa...

Authors: Ralph Weber, Dirk Bartig, Christos Krogias, Daniel Richter, Werner Hacke and Jens Eyding

Effects of state-wide implementation of the Los Angeles Motor Scale for triage of stroke patients in clinical practice

The prehospital identification of stroke patients with large-vessel occlusion (LVO), that should be immediately transported to a thrombectomy capable centre is an unsolved problem. Our aim was to determine whe...

Authors: Stefanie Behnke, Thomas Schlechtriemen, Andreas Binder, Monika Bachhuber, Mark Becker, Benedikt Trauth, Martin Lesmeister, Elmar Spüntrup, Silke Walter, Lukas Hoor, Andreas Ragoschke-Schumm, Fatma Merzou, Luca Tarantini, Thomas Bertsch, Jürgen Guldner, Achim Magull-Seltenreich…

Sensory trick effect in craniofacial dystonia as one of the possible impacts of wearing face masks during the COVID-19 pandemic

The report of a patient with blepharospasm during the COVID-19 pandemic suggested a potential ameliorating effect of wearing a face mask.

Authors: Frank Erbguth and Rüdiger Lange

Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/anti-SOX1 and VGCC antibodies

Anti-glial nuclear antibody (AGNA) is an onconeuroal antibody targeting the nuclei of Bergmann glia in the cerebellum and Anti-SRY-related HMG-box 1 (SOX1). It is highly specific for small cell lung cancer (SC...

Authors: Jonas Feldheim, Cornelius Deuschl, Martin Glas, Christoph Kleinschnitz and Tim Hagenacker

N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo, controlled randomized clinical trial

Oral administration of N,N-Dimethylglycine (DMG), a tertiary amino acid, presumably enhances oxygen utilization by tissue and complex with free radicals. Beneficial effects are improved endurance performance a...

Authors: Thomas Wolfsegger, Klaus Böck, Wolfgang Schimetta, Tim J. von Oertzen and Hamid Assar

Chronic intracranial hypertension after cerebral venous and sinus thrombosis – frequency and risk factors

Cerebral venous sinus thrombosis (CVST) can infrequently lead to chronical intracranial hypertension (IH) due to the altered venous drainage. The aim of this study was to ascertain the risk of IH after CVST an...

Authors: Christina Geisbüsch, Christian Herweh, Christoph Gumbinger, Peter A. Ringleb, Markus A. Möhlenbruch and Simon Nagel

Emergency intubation during thrombectomy for acute ischemic stroke in patients under primary procedural sedation

Emergency intubation is an inherent risk of procedural sedation regimens for endovascular treatment (EVT) of acute ischemic stroke. We aimed to characterize the subgroup of patients, who had to be emergently i...

Authors: Min Chen, Dorothea Kronsteiner, Johannes A. R. Pfaff, Simon Schieber, Martin Bendszus, Meinhard Kieser, Wolfgang Wick, Markus A. Möhlenbruch, Peter A. Ringleb, Julian Bösel and Silvia Schönenberger

Standardized Endoscopic Swallowing Evaluation for Tracheostomy Decannulation in Critically Ill Neurologic Patients – a prospective evaluation

Removal of a tracheostomy tube in critically ill neurologic patients is a critical issue during intensive care treatment, particularly due to severe dysphagia and insufficient airway protection. The “Standardi...

Authors: Paul Muhle, Sonja Suntrup-Krueger, Karoline Burkardt, Sriramya Lapa, Mao Ogawa, Inga Claus, Bendix Labeit, Sigrid Ahring, Stephan Oelenberg, Tobias Warnecke and Rainer Dziewas

Treatment of progressive multiple sclerosis with high-dose all-trans retinoic acid – no clear evidence of positive disease modifying effects

All-trans retinoic acid (ATRA) is an acid derivative of vitamin A which is discussed as a promising candidate to ameliorate the disease course of multiple sclerosis (MS) by immunomodulation or even by promoting r...

Authors: Christoph Ruschil, Evelyn Dubois, Maria-Ioanna Stefanou, Markus Christian Kowarik, Ulf Ziemann, Marcus Schittenhelm, Markus Krumbholz and Felix Bischof

Diagnosis and treatment of neurogenic dysphagia – S1 guideline of the German Society of Neurology

Neurogenic dysphagia defines swallowing disorders caused by diseases of the central and peripheral nervous system, neuromuscular transmission, or muscles. Neurogenic dysphagia is one of the most common and at ...

Authors: Rainer Dziewas, Hans-Dieter Allescher, Ilia Aroyo, Gudrun Bartolome, Ulrike Beilenhoff, Jörg Bohlender, Helga Breitbach-Snowdon, Klemens Fheodoroff, Jörg Glahn, Hans-Jürgen Heppner, Karl Hörmann, Christian Ledl, Christoph Lücking, Peter Pokieser, Joerg C. Schefold, Heidrun Schröter-Morasch…

Prognostication after intracerebral hemorrhage: a review

Approximately half of patients with spontaneous intracerebral hemorrhage (ICH) die within 1 year. Prognostication in this context is of great importance, to guide goals of care discussions, clinical decision-m...

Authors: Jens Witsch, Bob Siegerink, Christian H. Nolte, Maximilian Sprügel, Thorsten Steiner, Matthias Endres and Hagen B. Huttner

Mechanical thrombectomy in patients with cervical artery dissection and stroke in the anterior or posterior circulation – a multicenter analysis from the German Stroke Registry

Cervical artery dissection (CAD) is a rare cause of acute ischemic stroke (AIS) with large vessel occlusion (LVO) and may constitute a challenge for mechanical thrombectomy (MT). We compared procedural charact...

Authors: Ludwig Schlemm, Regina von Rennenberg, Eberhard Siebert, Georg Bohner, Fabian Flottmann, Gabor C. Petzold, Götz Thomalla, Matthias Endres and Christian H. Nolte

Stopping “transient ischemic attacks” by antiplatelet withdrawal

Transient ischemic attack (TIA) is considered to be an important risk factor for the development of ischemic stroke and requires complete etiopathogenic evaluation and prompt initiation of secondary prevention...

Authors: Lina Palaiodimou, Aikaterini Theodorou, Stefanos Lachanis, George P. Paraskevas, Matilda Papathanasiou, Christina Zompola, Konstantinos I. Voumvourakis and Georgios Tsivgoulis