Articles

Molecular mechanisms of proteinopathies across neurodegenerative disease: a review

Although there is a range of different symptoms across neurodegenerative diseases, they have been noted to have common pathogenic features. An archetypal feature shared between these diseases is protein misfol...

Authors: Alexander P. Marsh

The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial

Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, a drug that inhibits viral replication. Despite antiviral...

Authors: U. Meyding-Lamadé, C. Jacobi, F. Martinez-Torres, T. Lenhard, B. Kress, M. Kieser, C. Klose, K. Einhäupl, J. Bösel, M-B Mackert, V. Homberg, C. Koennecke, G. Weißheit, D. Claus, B. Kieseier, J. Bardutzky…

Conditioned pain modulation in drug-naïve patients with de novo Parkinson’s disease

Pain is highly prevalent in patients with Parkinson’s disease (PD), but underlying pathophysiological mechanisms are largely unclear. In many chronic pain syndromes deficits in endogenous pain inhibition have ...

Authors: Wiebke Grashorn, Odette Fründt, Carsten Buhmann, Nathalie Wrobel, Katharina Schmidt and Ulrike Bingel

An omics-based strategy using coenzyme Q10 in patients with Parkinson’s disease: concept evaluation in a double-blind randomized placebo-controlled parallel group trial

This study focuses on genetically stratified subgroups of Parkinson’s disease patients (PD) with an enrichment of risk variants in mitochondrial genes,who might benefit from treatment with the “mitochondrial e...

Authors: Jannik Prasuhn, Norbert Brüggemann, Nicole Hessler, Daniela Berg, Thomas Gasser, Kathrin Brockmann, Denise Olbrich, Andreas Ziegler, Inke R. König, Christine Klein and Meike Kasten

Human immunodeficiency virus and multiple sclerosis: a review of the literature

Multiple sclerosis (MS) and human immunodeficiency virus (HIV) infection are frequent and well-studied nosological entities. Yet, comorbidity of MS and HIV has only been rarely reported in the medical literatu...

Authors: Maria-Ioanna Stefanou, Markus Krumbholz, Ulf Ziemann and Markus C. Kowarik

Computer-aided imaging analysis in acute ischemic stroke – background and clinical applications

Tools for medical image analysis have been developed to reduce the time needed to detect abnormalities and to provide more accurate results. Particularly, tools based on artificial intelligence and machine lea...

Authors: Yahia Mokli, Johannes Pfaff, Daniel Pinto dos Santos, Christian Herweh and Simon Nagel

SOP myasthenic crisis

The overall prevalence of myasthenic crisis is quite low at 30/1 million inhabitants because myasthenia gravis is a rare disease per se. But it should be noted that 15–20% of patients with myasthenia gravis ex...

Authors: Henning Stetefeld and Michael Schroeter

An unmet clinical need: roads to remyelination in MS

In the central nervous system (CNS) myelin sheaths stabilize, protect, and electrically insulate axons. However, in demyelinating autoimmune CNS diseases such as multiple sclerosis (MS) these sheaths are destr...

Authors: Peter Göttle, Moritz Förster, Vivien Weyers, Patrick Küry, Konrad Rejdak, Hans-Peter Hartung and David Kremer

New alternative splicing variants of the ATXN2 transcript

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells and selective loss of neurons in the brainstem. This neurodegenerative disorder...

Authors: Isabel Lastres-Becker, David Nonis, Joachim Nowock and Georg Auburger

HDMTX-based induction therapy followed by consolidation with conventional systemic chemotherapy and intraventricular therapy (modified Bonn protocol) in primary CNS lymphoma: a monocentric retrospective analysis

To evaluate outcome and toxicity of High-dose methotrexate (HDMTX)-based induction therapy followed by consolidation with conventional systemic chemotherapy and facultative intraventricular therapy (modified B...

Authors: Sabine Seidel, Agnieszka Korfel, Thomas Kowalski, Michelle Margold, Fatme Ismail, Roland Schroers, Alexander Baraniskin, Hendrik Pels, Peter Martus and Uwe Schlegel

Emerging and re-emerging viruses affecting the nervous system

Emerging and re-emerging viruses may cause meningitis, encephalitis, meningoencephalomyelitis, encephalitis, Guillian-Barré-like-syndromes as well as strokes. Most important viruses belong to the family of Adenov...

Authors: Uta Meyding-Lamadé, Eva Craemer and Paul Schnitzler

Functional stroke outcomes after mobile stroke unit deployment – the revised protocol for the Berlin Prehospital Or Usual Delivery of acute stroke care (B_PROUD) part 2 study

Studies investigating the Mobile Stroke Unit (MSU) concept have shown increased thrombolysis rates, reduced alarm-to-treatment times and improved prehospital triage. Yet, so far, there is no definite scientifi...

Authors: Peter Harmel, Martin Ebinger, Erik Freitag, Ulrike Grittner, Irina Lorenz-Meyer, Ira Napierkowski, Christian H. Nolte, Bob Siegerink and Heinrich J. Audebert

Ulnar nerve integrity predicts 1-year outcome in cervical spinal cord injury

Accurate predictors of neurological recovery after cervical spinal cord injury are needed. Particularly, to tailor adequate rehabilitation plans. However, objective and quantifiable predictors are sparse.

Authors: Andreas Hug, Christian Schuld, Bettina Mürle, Markus Böttinger, Norbert Weidner and Rüdiger Rupp

Cerebral involvement in systemic vasculitides

Cerebral vasculitis is a rare disorder but plays a major role in the differential diagnosis of stroke, encephalopathy and headache. This guideline was developed in order to support clinicians in the diagnosis ...

Authors: Peter Berlit and Markus Krämer

Resumption of oral anticoagulation after spontaneous intracerebral hemorrhage

Given an ageing population the incidence of both patients suffering from intracerebral hemorrhage (ICH) and those requiring oral anticoagulation will increase. Up to now there are no results from randomized tr...

Authors: Jochen A. Sembill, Joji B. Kuramatsu, Stefan Schwab and Hagen B. Huttner

Aneurysmatic subarachnoid haemorrhage

Aneurysmatic Subarachnoid Haemorrhage (aSAH) is typically caused by extravasated blood in the subarachnoid space due to a ruptured aneurysm. aSAH is often life-threatening in the acute stage, but may also caus...

Authors: Oezguer A. Onur, Gereon R. Fink, Joji B. Kuramatsu and Stefan Schwab

Historical review: a short history of German neurology – from its origins to the 1940s

This paper aims at reconstructing the development and role of German neurology between 1840 and 1940. Therefore a couple of original sources as well as selected material form the scattered secondary literature...

Authors: A. Karenberg, H. Fangerau, H. Steinmetz, P. Berlit and M. Grond

Safety and clinical impact of FEES – results of the FEES-registry

At present, the flexible endoscopic evaluation of swallowing (FEES) is one of the most commonly used methods for the objective assessment of swallowing. This multicenter trial prospectively collected data on t...

Authors: Rainer Dziewas, Matthias auf dem Brinke, Ulrich Birkmann, Götz Bräuer, Kolja Busch, Franziska Cerra, Renate Damm-Lunau, Juliane Dunkel, Amelie Fellgiebel, Elisabeth Garms, Jörg Glahn, Sandra Hagen, Sophie Held, Christine Helfer, Mirko Hiller, Christina Horn-Schenk…

Primary angiitis of the CNS (PACNS) and Behçet disease

Cerebral vasculitis is a rare disorder but plays a major role in the differential diagnosis of stroke, encephalopathy and headache. This guideline was developed in order to support clinicians in the diagnosis ...

Authors: Peter Berlit and Markus Krämer

Neurobiology and clinical features of impulse control failure in Parkinson’s disease

Impulse control disorders (ICDs) and other impulsive-compulsive related behaviours are frequent and still under recognized non-motor complications of Parkinson’s disease (PD). They result from sensitization of...

Authors: Matthieu Béreau, Paul Krack, Norbert Brüggemann and Thomas F. Münte

Socioeconomic decline and advancement within and between generations and the risk of stroke - a case-control study

Disadvantageous socioeconomic conditions (SEC) in both childhood and adulthood increase the risk of stroke. We investigated whether intergenerational and lifetime social advancement decreases and/or social des...

Authors: Armin J. Grau, Annette Aigner, Christian Urbanek, Frederik Palm, Florian Buggle, Anton Safer and Heiko Becher

Announcing the new launch of Neurological Research and Practice

Authors: Werner Hacke

GCS 15: when mild TBI isn’t so mild

The present study characterizes patients with the mildest of mild traumatic brain injury (TBI), as defined by a Glasgow coma score (GCS) of 15.

Authors: Latha Ganti, Tej Stead, Yasamin Daneshvar, Aakash N. Bodhit, Christa Pulvino, Sarah W. Ayala and Keith R. Peters

Navigating choice in multiple sclerosis management

With the advent of modern immunotherapies for relapsing-remitting multiple sclerosis (RRMS) and the increasing amount of treatment options on the market, MS has evolved as a treatable disease. Yet, at the same...

Authors: Ralf A. Linker and Andrew Chan

Distribution and evolution of acute interventional ischemic stroke treatment in Germany from 2010 to 2016

Mechanical thrombectomy (MT) is a new evidence-based treatment option for large vessel occlusion in the anterior brain circulation. Using comprehensive administrative data from Germany, we analysed the nationw...

Authors: Ralph Weber, Jens Eyding, Martin Kitzrow, Dirk Bartig, Christian Weimar, Werner Hacke and Christos Krogias

SOP: First-ever epileptic seizure in adult patients

About 5% of all adults will have at least one epileptic seizure in their life. The incidence of all unprovoked seizures ranges from approximately 50 to 70 /100,000. The very first epileptic seizure in an adult...

Authors: Julian Bösel

Pallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)

Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia. Pallidal neurostimulation is a potent alternative, but currently re...

Authors: Thorsten M. Odorfer, Uwe Malzahn, Cordula Matthies, Peter U. Heuschmann and Jens Volkmann

Cryptogenic stroke and patent foramen ovale (abridged and translated version)

Interventional patent foramen ovale (PFO) closure should be performed in patients aged 16 to 60 years (after extensive neurological and cardiological diagnostic work-up) with a history of cryptogenic ischaemic...

Authors: Hans-Christoph Diener, Armin Grau and Stephan Baldus