First line |
Corticosteroids | No details on doses or durations given |
Plasma exchange |
Intravenous immunoglobulins |
Second line (if first line did not work within 10 daysa) |
Rituximab | 4 × 375 mg/m2 i.v., weekly administration |
Cyclophosphamideb | 750 mg/m2 i.v. per month |
- aThis has been said for anti-NMDAR encephalitis. In other, less severe forms of autoimmune encephalitis, one may wait longer before one moves on to second-line therapy. bIn pediatric patients, cyclophosphamide is less frequently used compared to rituximab