Table 12 Frequency of abnormal changes in routine CSF parameters in patients with multiple sclerosis [150]
From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)
Parameter | Diagnostic LP | Remarks |
|---|---|---|
Cell count | ≤4/μL: 40% 5-30/μL: 55% > 30/μL: 5% | Depends on LP and relapse time interval and on topography of lesion |
Differential cell count | - lymphomonocytic: 100% - activiated lymphocytes or plasma cells (< 5% of all cells): 50-60% | |
Albumin ratio | < 8 × 10−3: 90% 8-25 × 10− 3: 10% | Depends on LP and relapse time interval and on topography of lesion |
Intrathecal IgG, IgA, and IgM synthesis in Reiber diagrams | IgG > 0%: 72% IgA > 0%: 8% IgM > 0%: 20% | In clinically confirmed MS |
OCB | CSF specific OCB (Type 2 oder 3 patterns): 88-98% | |
MRZ reaction | Measles: 78% Rubella: 60% Zoster: 55% | Positive in clinical definite MS, if AI > 1,4 for two of the viruses |