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Table 12 Frequency of abnormal changes in routine CSF parameters in patients with multiple sclerosis [150]

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

Parameter Diagnostic LP Remarks
Cell count ≤4/μL: 40%
5-30/μL: 55%
> 30/μL: 5%
Depends on LP and relapse time interval and on topography of lesion
Differential cell count - lymphomonocytic: 100%
- activiated lymphocytes or
plasma cells (<  5% of all cells): 50-60%
 
Albumin ratio < 8 × 10−3: 90%
8-25 × 10− 3: 10%
Depends on LP and relapse time interval and on topography of lesion
Intrathecal IgG, IgA, and IgM synthesis in Reiber diagrams IgG > 0%: 72%
IgA > 0%: 8%
IgM > 0%: 20%
In clinically confirmed MS
OCB CSF specific OCB
(Type 2 oder 3 patterns): 88-98%
 
MRZ reaction Measles: 78%
Rubella: 60%
Zoster: 55%
Positive in clinical definite MS, if AI > 1,4 for two of the viruses
  1. AI Antibody index, Ig Immunglobulin, MS Multiple sclerosis, OCB oligoclonal band