Table 14 CSF findings in patients with neurosarcoidosis
From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)
Parameter | Diagnostic LP | Follow-up LP (under steroid treatment) | Remarks |
|---|---|---|---|
Cell count | 0 to 575/μL < 5/μL 20% 5-30/μL 30% > 30/μL 50% | normalzed | Higher cell counts in leptomeningeal forms |
Cell type | Predominantly lymphocytes | Basophilic and eosinophilic granulocytes possible | |
CD4/CD8 ratio in CSF | No data available | ||
Glucose ratio serum/CSF | < 0,4 in 50% | Glucose level may be reduced, but glucose ratio is more precise | |
Lactate in CSF | elevated | Few data | |
Albumin ratio | 8-25 × 10−3: 25 up to 100% | Total protein is generally elevated, but albumin ratio is more precise | |
intrathecal IgG, IgA, and IgM-synthesis | 13 to 80% | Few data, intrathecal IgA production is seen | |
OCB | CSF-specific OCB (type 2 or 3): 0-70% | ||
ACE in CSF | 20% | Genotype has an impact; thus sensitivity is low | |
soluble IL 2 receptor in CSF | elevated | Only in active disease and untreated patients |