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Table 14 CSF findings in patients with neurosarcoidosis

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

Parameter Diagnostic LP Follow-up LP (under steroid treatment) Remarks
Cell count 0 to 575/μL
< 5/μL 20%
5-30/μL 30%
> 30/μL 50%
normalzed Higher cell counts in leptomeningeal forms
Cell type Predominantly lymphocytes   Basophilic and eosinophilic granulocytes possible
CD4/CD8 ratio in CSF No data available   
Glucose ratio serum/CSF < 0,4 in 50%   Glucose level may be reduced, but glucose ratio is more precise
Lactate in CSF elevated   Few data
Albumin ratio 8-25 × 10−3:
25 up to 100%
  Total protein is generally elevated, but albumin ratio is more precise
intrathecal IgG, IgA, and IgM-synthesis 13 to 80%   Few data, intrathecal IgA production is seen
OCB CSF-specific OCB (type 2 or 3): 0-70%   
ACE in CSF 20%   Genotype has an impact; thus sensitivity is low
soluble IL 2 receptor in CSF elevated   Only in active disease and untreated patients