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Table 14 CSF findings in patients with neurosarcoidosis

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

ParameterDiagnostic LPFollow-up LP (under steroid treatment)Remarks
Cell count0 to 575/μL
< 5/μL 20%
5-30/μL 30%
> 30/μL 50%
normalzedHigher cell counts in leptomeningeal forms
Cell typePredominantly lymphocytes Basophilic and eosinophilic granulocytes possible
CD4/CD8 ratio in CSFNo data available  
Glucose ratio serum/CSF< 0,4 in 50% Glucose level may be reduced, but glucose ratio is more precise
Lactate in CSFelevated Few data
Albumin ratio8-25 × 10−3:
25 up to 100%
 Total protein is generally elevated, but albumin ratio is more precise
intrathecal IgG, IgA, and IgM-synthesis13 to 80% Few data, intrathecal IgA production is seen
OCBCSF-specific OCB (type 2 or 3): 0-70%  
ACE in CSF20% Genotype has an impact; thus sensitivity is low
soluble IL 2 receptor in CSFelevated Only in active disease and untreated patients