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Table 2 Recommendations for diagnostic LP in thrombocytopenia (see also cross-sectional guideline of the Bundesärztekammer on therapy with blood components and plasma derivatives (

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

Thrombocyte count /μL Procedure for a planned LP
> 50,000 If there are no other contraindications.
10,000–50,000 Relative contraindication. An increased risk of bleeding is to be expected. Substitute thrombocytes if necessary.
< 10,000 Absolute contraindication. Thrombocyte substitution before LP mandatory.