Skip to main content

Table 9 Typical CSF findings in acute and subacute phases of viral CNS infections

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

ParameterFindings (diagnostic LP (days 1-7), before therapy)Findings (follow-up LP (days > 10-14), during therapy)
CSF appearanceclearclear
Cell count (Leukocytes/μL)5 – 1000<<  1000
Differential cell countlymphomonocytic, in initial phase (days 1-3) small fraction of neutrophilslymphomonocytic
Albumin ratio (L/S × 10−3)<  20< 10
Intrathecal Ig-SynthesisNoYes
Total protein (mg/L)<  1000<< 1000
Lactate (mmol/L)<  3.5< 3.5
PCR in CSFpositivenegative
Antibody indexNot detectable or < 1.5> 1.4