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Table 9 Typical CSF findings in acute and subacute phases of viral CNS infections

From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

Parameter Findings (diagnostic LP (days 1-7), before therapy) Findings (follow-up LP (days > 10-14), during therapy)
CSF appearance clear clear
Cell count (Leukocytes/μL) 5 – 1000 <<  1000
Differential cell count lymphomonocytic, in initial phase (days 1-3) small fraction of neutrophils lymphomonocytic
Albumin ratio (L/S × 10−3) <  20 < 10
Intrathecal Ig-Synthesis No Yes
Total protein (mg/L) <  1000 << 1000
Lactate (mmol/L) <  3.5 < 3.5
PCR in CSF positive negative
Antibody index Not detectable or < 1.5 > 1.4