Table 1 Baseline characteristics

 Age – years, median (IQR), n

76 (65–82), n = 2527

51 (43–57), n = 62

<.001

 Female, % (n)

50.9% (1286)

25.8% (16)

<.001

 0

68.0% (1652)

95.2% (59)

<.001

 1

12.8% (310)

0% (0)

 2

8.3% (201)

3.2% (2)

 3

6.0% (145)

1.6% (1)

 4

3.5% (86)

0% (0)

 5

1.4% (35)

0% (0)

Current smoking, % (n)

15.0% (332)

24.1% (13)

.160

 NIHSS, median (IQR), n

15 (10–19), n = 2527

14 (7–17), n = 62

.107

 Hypertension

76.8% (1925)

25.8% (16)

<.001

 Diabetes mellitus

21.3% (535)

4.8% (3)

<.001

 Dyslipidemia

34.1% (854)

17.7% (11)

.006

 Atrial fibrillation

41.9% (1049)

1.6% (1)

<.001

 Antiplatelet

33.5% (822)

17.7% (11)

.009

 Anticoagulation

21.0% (515)

1.6% (1)

<.001

 Cardioembolism

51.7% (1307)

–

–

 Dissection

–

100.0% (62)

 Large-artery atherosclerosis

25.9% (654)

–

 Small-vessel occlusion

0.0% (1)

–

 Stroke of other determined etiology

4.8% (122)

–

 Stroke of undetermined etiology

17.5% (443)

–

Direct-to-center, % (n)

52.0% (1313)

54.8% (34)

.701

Symptom onset known, % (n)

61.5% (1553)

74.2% (46)

.047

Time from symptom onset to admission – min, median (IQR), n

127 (59–206), n = 1553

119 (54–185), n = 46

.728

Time from last-seen-well to admission – min, median (IQR), n

357 (202–685), n = 974

283 (200–339), n = 16

.163

 ASPECTS, median (IQR), n

9 (7–10), n = 1904

8 (6–10), n = 37

.025

  ICA

24.5% (614)

45.2% (28)

<.001

  MCA, M1

56.7% (1423)

29.0% (18)

<.001

  MCA, M2

17.7% (444)

19.4% (12)

.420

  ACA

2.5% (62)

0.0% (0)

.403

  BA

10.2% 255)

19.4% (12)

.032

  VA

1.7% (42)

17.7% (11)

<.001

  PCA

2.2% (55)

1.6% (1)

1.000

 0

85.9% (2088)

86.7% (52)

.801

 1

4.8% (117)

5.0% (3)

 2a

2.1% (50)

1.7% (1)

 2b

3.1% (75)

5.0% (3)

 3

4.2% (102)

1.7% (1)

Extracranial ICA stenosis (> 70%)

ipsilateral to intracranial vessel

occlusion, % (n/n)

14.1% (334)

46.7% (28)

<.001