Fig. 1

Schematic overview of treatment plan and clinical outcome. a Schematic overview of the planned treatment, consisting of 30 days of induction therapy followed by 3 cycles of consolidation therapy and 6 cycles of sustainment therapy. Due to lack of evidence and potential aggravation of disease activity, treatment was stopped after the 2nd cycle of sustainment / day 300. b Clinical course of EDSS and c clinical course of walking ability. Slight non-significant improvement was observed on day 210 that was not statistically significant and could not be proven on day 300. d MSFC z score did not show significant changes. All tests showed no significance (p < 0,05) in Friedman-test with Dunn’s post-hoc test