Fig. 2

Synopsis of all histological criteria and their characteristic features The number of platelets is determined by immunohistochemical staining (CD61). The property of the fibrin net is determined by hematoxylin–eosin (HE) and Elastica-van Gieson staining (EvG). The number of neutrophil granulocytes, as well as the proportion of intact neutrophils and red cells to the total number of the respective blood cells, is classified by HE. The number of platelets and neutrophils is described by categorical scale using the characteristic features “few “, “moderate “, and “many “. Continuous percentage scales are used to specify the property of fibrin net subdivided in the characteristic features “fine “, “coarse “, and “dense “ and to define the proportions of intact neutrophils and red cells to their total numbers. Following the terms of cloud formations, the distribution of platelets is described as “stratus “, “cirrus “, or “cumulus “. Vivid pictures are published in [8]. The histological cross-sections were captured with 200-fold original magnification. Only the fibrin net was pictured with 400-fold original magnification