Table 2 Adjustment of vascular risk factors over time and comparison of study groups; n = 513

Systolic BP D0 (median [IQR])^□

147 (131; 160)

145 (130; 162)

150 (133; 160)

146 (130; 160)

0.7317^◊

Diastolic BP D0 (median [IQR])^□

80 (72; 88)

80 (74; 90)

80 (75; 89)

80 (73; 89)

0.5734^◊

Systolic BP D30 (median [IQR])

142 (131; 160)

140 (130; 154)

141 (130; 160)

142 (130; 160)

0.2178^◊

0.0005^⌂*

Diastolic BP D30 (median [IQR])

80 (71; 85)

80 (71; 87)

80 (70; 89)

80 (71; 86)

0.9233^◊

0.0160^⌂*

Systolic BP M6 (median [IQR])

144.5 (130; 158)

140 (130; 159)

140 (128; 160)

141 (130; 159)

0.6510^◊

 < 0.0001^⌂*

Diastolic BP M6 (median [IQR])

80 (70; 87)

80 (74; 86)

80 (72; 86)

80 (72; 86)

0.4862^◊

0.0035^⌂*

Systolic BP A1 (median [IQR])

142.5 (130; 158)

140 (130; 156)

140 (130; 150)

140 (130; 157)

0.6320^◊

 < 0.0001^⌂*

Diastolic BP A1 (median [IQR])

80 (70.5; 85)

80 (72; 85)

80 (70; 85)

80 (71; 85)

0.8059^◊

0.0001^⌂*

Blood glucose (median [IQR]) D0^□

103.5 (92; 121)

104 (93; 125)

104 (92; 119)

104 (92.5; 122)

0.8918^◊

Blood glucose (median [IQR]) D30

110.5 (95; 131)

105 (95; 125)

101 (92; 121)

107 (94; 125)

0.2776^◊

0.1054^⌂

Blood glucose (median [IQR]) M6

108 (96; 125)

103 (94; 126)

101 (92.5; 123)

104 (94; 125)

0.3761^◊

0.8950^⌂

Blood glucose (median [IQR]) A1

105 (93; 124)

105 (93; 124)

105.5 (96.5; 127)

105 (94; 124.5)

0.6192^◊

0.2191^⌂

HbA1c (in %; median [IQR]) D0^□

6 (5.7; 6.45)

6 (5.7; 6.6)

5.9 (5.55; 6.75)

6 (5.7; 6.5)

0.5940^◊

HbA1c (in %; median [IQR]) D30

5.9 (5.6; 6.4)

5.9 (5.6; 6.4)

5.9 (5.5; 6.6)

5.9 (5.6; 6.4)

0.7903^◊

0.0025^⌂*

HbA1c (in %; median [IQR]) M6

6.1 (5.7; 6.6)

6.0 (5.7; 6.4)

5.9 (5.5; 6.7)

6.0 (5.7; 6.5)

0.4636^◊

0.7925^⌂

HbA1c (in %; median [IQR]) A1

6.0 (5.5; 6.5)

5.9 (5.7; 6.5)

6.0 (5.5; 6.7)

6.0 (5.6; 6.5)

0.9039^◊

0.5419^⌂

Cholesterol (median [IQR]) D0^□

181 (153; 209)

173.5 (152; 200)

169.5 (146.5; 192.5)

174 (151; 203)

0.2619^◊

Cholesterol (median [IQR]) D30

175 (149; 207)

168 (150.5; 193.5)

159 (142; 191)

168.5 (148; 196)

0.0744^◊

0.0025^⌂*

Cholesterol (median [IQR]) M6

176 (149; 199)

170 (150; 194)

161 (143; 175)

168 (147; 194)

0.0056^◊*

0.0091^⌂*

Cholesterol (median [IQR]) A1

174 (150; 202)

167 (143; 198)

164 (140; 184)

167 (146; 194)

0.0385^◊*

0.0017^⌂*

LDL-Cholesterol (median [IQR]) D0^□

105 (81; 130)

98.5 (80; 126)

97 (80; 117)

99 (80; 123.5)

0.3559^◊

LDL-Cholesterol (median [IQR]) D30

98 (78; 125)

91 (76; 114)

88 (72; 106)

91 (76; 116)

0.0985^◊

0.0001^⌂*

LDL-Cholesterol (median [IQR]) M6

98 (75; 119)

95 (80; 115)

87 (72; 103)

92 (75; 113)

0.0286^◊*

0.0006^⌂*

LDL-Cholesterol (median [IQR]) A1

98 (78; 118)

93 (72; 116)

87 (69; 108)

93 (73; 116)

0.1164^◊

0.0001^⌂*

HDL-Cholesterol (median [IQR]) D0^□

48 (40; 62)

49 (40; 56.5)

49 (41.5; 57.5)

49 (41; 58)

0.8799^◊

HDL-Cholesterol (median [IQR]) D30

50 (40; 60)

48 (40; 60)

50 (41; 59)

49 (41; 60)

0.6703^◊

0.8535^⌂

HDL-Cholesterol (median [IQR]) M6

49 (40; 60)

49 (41; 60)

48 (41; 56)

49 (41; 59)

0.8393^◊

0.6249^⌂

HDL-Cholesterol (median [IQR]) A1

48 (41; 59.5)

49 (40; 58.5)

49.5 (41.5; 60)

49 (41; 59.5)

0.9204^◊

0.0592^⌂

Triglycerides (median [IQR]) D0^□

131 (98; 182.5)

128.5 (92; 184)

120 (91; 181)

126.5 (94; 182)

0.6626^◊

Triglycerides (median [IQR]) D30

121 (92, 207)

114 (87; 174)

121 (87; 181)

119 (88; 181)

0.5671^◊

0.0893^⌂

Triglycerides (median [IQR]) M6

133.5 (94; 192)

124 (90; 164)

107 (78; 143)

122.5 (89; 173.5)

0.0123^◊*

0.0581^⌂

Triglycerides (median [IQR]) A1

136 (97; 192)

112.5 (88; 182)

132 (91; 173)

127 (91; 183)

0.0920^◊

0.5763^⌂

BMI D0 (median [IQR])^□

27 (25; 30)

27 (25; 30)

27 (24; 29)

27 (25; 30)

0.3567^◊

BMI D30 (median [IQR])

27 (25; 30)

27 (25; 30)

26.5 (24; 29)

27 (25; 30)

0.1906^◊

0.0001^⌂*

BMI M6 (median [IQR])

27 (25; 30)

27.5 (25; 30)

27 (24; 29)

27 (25; 30)

0.2135^◊

0.3891^⌂

BMI A1 (median [IQR])

27 (25; 29.5)

27 (25; 30)

26 (24; 30)

27 (25; 30)

0.5458^◊

0.1201^⌂

WHR D0 (median [IQR])

0.97 (0.93; 1.02)

0.98 (0.94; 1.04)

0.99 (0.95; 1.03)

0.98 (0.94; 1.03)

0.1514^◊

WHR D30 (median [IQR])

0.98 (0.93; 1.03)

0.98 (0.94; 1.03)

0.99 (0.93; 1.03)

0.98 (0.93; 1.03)

0.7593^◊

0.8432^⌂

WHR M6 (median [IQR])

0.98 (0.95; 1.02)

0.97 (0.93; 1.02)

1.00 (0.94; 1.03)

0.98 (0.94; 1.02)

0.2148^◊

0.3083^⌂

WHR A1 (median [IQR])

0.99 (0.95; 1.02)

0.98 (0.92; 1.03)

0.99 (0.94; 1.03)

0.98 (0.94; 1.02)

0.6700^◊

0.7363^⌂

Physical activity > 30 min/week D30 (% [n])

 None

24.9% (46)

26.2% (45)

11.4% (12)

22.3% (103)

0.024 ^⌐*

 1–2 times

22.7% (42)

24.4% (42)

21.9% (23)

23.2% (107)

 3 times or more

52.4% (97)

49.4% (85)

66.7% (70)

54.5% (252)

Physical activity > 30 min/week M6 (% [n])

 None

20.2% (36)

25.6% (44)

17.1% (18)

21.5% (98)

0.267^⌐

 1–2 times

25.8% (46)

19.8% (34)

20.0% (21)

22.2% (101)

 3 times or more

53.9% (96)

54.7% (94)

62.9% (66)

56.3% (256)

Physical activity > 30 min/week A1 (% [n])

 None

19.8% (34)

23.2% (39)

16.8% (17)

20.4% (90)

0.069^⌐

 1–2 times

33.1% (57)

21.4% (36)

22.8% (23)

26.3% (116)

 3 times or more

47.1% (81)

55.4% (93)

60.4% (61)

53.3% (235)

Implementation of RFM at D30 (% [n])

74.4% (131)

63.9% (108)

68.0% (70)

69.0% (309)

0.104^⌐

Implementation of RFM at M6 (% [n])

67.8% (116)

53.7% (88)

76.0% (79)

64.5% (283)

 < 0.001*

Implementation of RFM at A1 (% [n])

64.7% (110)

60.8% (101)

76.8% (76)

66.0% (287)

0.027^⌐*