Table 1 Demographics, baseline risk factors, and clinical data of recruited patients with ICH
From: The “SALPARE study” of spontaneous intracerebral hemorrhage: part 1
All centers (n = 682) | Padova (n = 320) | Salerno (n = 180) | Reggio Emilia (n = 182) | p | ||
|---|---|---|---|---|---|---|
Age (years, mean ± SD) | 73 ± 14 | 73 ± 14 | 72 ± 13 | 75 ± 13 | NS | |
Sex | Male, n (%) | 366 (54%) | 157 (49%) | 104 (58%) | 105 (58%) | NS |
Family history of ICH | Yes, n (%) | 11 (2%) | 9 (3%) | 2 (1%) | 0 | NS |
Smoking | Yes, n (%) | 185 (27%) | 77 (24%) | 30 (17%)* | 78 (43%)* | < 0.01 |
History of previous cerebrovascular events | Yes, n (%) | 141 (20%) | 78 (24%) | 30 (16%) | 33 (18%) | NS |
Type of previous cerebrovascular | TIA | 14 (10%) | 9 (11%) | 4 (13%) | 1 (3%) | NS |
Ischemic stroke | 79 (56%) | 37 (48%) | 18 (60%) | 24 (73%) | NS | |
Hemorragic stroke | 43 (30%) | 28 (36%) | 8 (27%) | 7 (21%) | NS | |
Both | 5 (4%) | 4 (5%) | 0 | 1 (3%) | NS | |
History of previous cardiovascular events | Yes, n (%) | 115 (17%) | 39 (12%)* | 29 (16%) | 47 (26%)* | < 0.01 |
Diabetes mellitus | Yes, n (%) | 128 (19%) | 65 (20%) | 36 (20%) | 27 (15%) | NS |
Alcohol abuse (< 5 years) | Yes, n (%) | 50 (7%) | 25 (8%) | 7 (4%) | 18 (10%) | NS |
Drug abuse (< 5 years) | Yes, n (%) | 6 (1%) | 4 (1%) | 0 | 2 (1%) | NS |
Hypertension | Yes, n (%) | 464 (68%) | 243 (76%)* | 108 (60%)* | 113 (62%) | < 0.01 |
Chronic obstructive pulmonary disease | Yes, n (%) | 43 (6%) | 17 (5%) | 22 (12%)* | 4 (2%)* | < 0.01 |
Liver failure | Yes, n (%) | 35 (5%) | 24 (7%) | 6 (3%) | 5 (3%) | NS |
Anticoagulant therapy | VKA, n (%) | 74 (11%) | 40 (12.5%) | 17 (10%) | 21 (12%) | NS |
Non-VKA, n (%) | 53 (8%) | 34 (11%)* | 15 (8%) | 4 (2%)* | < 0.01 | |
Antiplatelet therapy | Single, n (%) | 194 (28%) | 104 (32%)* | 36 (20%)* | 56 (31%) | < 0.01 |
Dual, n (%) | 11 (1.6%) | 14 (4%) | 0 | 1 (0.5%) | NS | |
Blood glucose levels > 180 mg/dl, n (%) | 116 (17%) | 63 (20%) | 28 (16%) | 24 (13%) | NS | |
INR > 1.7, n (%) | 77 (11%) | 37 (12%) | 21 (12%) | 19 (10%) | NS | |
Platelet < 100*103/mm3, n (%) | 31 (5%) | 14 (4%) | 10 (5%) | 7 (4%) | NS | |
mRS pre-stroke | 0–2 | 474 (69%) | 241 (75%)* | 79 (44%)* | 151 (83%)* | < 0.01 |
3–5 | 98 (14%) | 73 (23%)* | 4 (2%)* | 23 (12%)* | < 0.01 | |
GCS at onset | ≤ 8, n (%) | 130 (19%) | 69 (22%)* | 25 (14%)* | 36 (20%) | NS |
9–13, n (%) | 120 (18%) | 68 (21%)* | 15 (8%)* | 37 (20%) | < 0.01 | |
> 13, n (%) | 306 (45%) | 174 (54%) | 32 (18%)* | 100 (55%)* | < 0.01 | |
NIHSS at onset, median (range) | 10 (0–40) | 10 (0–40) | 5 (0–25)* | 18 (1–28)* | < 0.01 | |