Table 2 List of approaches for improvement of future ICH-trials

- Improving selection criteria:

 o Limitation of max. eligible time from symptom onset to randomization/intervention (< 4.5 h)

 o Limitation of max. eligible ICH-volume on initial imaging (< 60ml)

 o Stratify for antithrombotic medication

 o Stratification of ICH locations

 o Radiological predictors (non-contrast and contrast medium imaging markers

 o Development of AI-based risk prediction models

- Standardizing the definition of HE (stratified according to ICH location)

- Endpoint selection:

 o Functional outcome assessment at ≥6 months

 o Shift analysis models for HE and outcome instead of dichotomization

 o Patient-oriented continuous outcome variable (e.g. QALYs)

 o Composite endpoints of radiological and clinical endpoints