Table 4 Area under the receiver operating curve (AUC) of S-SOFA and SOFA scores for the prediction of different outcome measures and their difference with 95% confidence intervals in the validation cohort and several subgroups (no treatment limitations, ICU treatment, non-ICU treatment)
From: Derivation and validation of a screening tool for stroke-associated sepsis
Predicted outcome | S-SOFA score | SOFA score | Difference | p-value for non-inferiority |
|---|---|---|---|---|
Full (n = 391) | ||||
Poor outcome at 3 months | 0.713 [0.665, 0.762] | 0.750 [0.703, 0.798] | -0.037 [-0.075, 0] | 0.115 |
Death during hospitalization | 0.727 [0.666, 0.788] | 0.789 [0.728, 0.849] | -0.062 [-0.12, -0.004] | 0.526 |
Death within 3 months | 0.684 [0.632, 0.736] | 0.724 [0.672, 0.775] | -0.040 [-0.081, 0.002] | 0.169 |
No treatment limitations (n = 228) | ||||
Poor outcome at 3 months | 0.688 [0.615; 0.761] | 0.707 [0.633; 0.781] | -0.019 [-0.073; 0.035] | 0.068 |
Death during hospitalization | 0.863 [0.688; 1.038] | 0.988 [0.965; 1.01] | -0.125 [-0.279; 0.029] | 0.795 |
Death within 3 months | 0.670 [0.567; 0.772] | 0.653 [0.534; 0.772] | 0.017 [-0.064; 0.098] | 0.032 |
ICU treatment (n = 95) | ||||
Poor outcome at 3 months | 0.770 [0.681, 0.860] | 0.780 [0.668, 0.893] | -0.010 [-0.131, 0.111] | 0.209 |
Death during hospitalization | 0.678 [0.571, 0.785] | 0.756 [0.659, 0.854] | -0.078 [-0.192, 0.035] | 0.625 |
Death within 3 months | 0.679 [0.575, 0.782] | 0.758 [0.661, 0.856] | -0.080 [-0.195, 0.035] | 0.633 |
ICU treatment and no treatment limitations (n = 50) | ||||
Poor outcome at 3 months | 0.770 [0.648; 0.893] | 0.732 [0.59; 0.874] | 0.038 [-0.111; 0.187] | 0.098 |
Death during hospitalization | 0.831 [0.593; 1.07] | 0.940 [0.829; 1.051] | -0.109 [-0.247; 0.029] | 0.756 |
Death within 3 months | 0.743 [0.527; 0.958] | 0.854 [0.697; 1.011] | -0.111 [-0.29; 0.067] | 0.713 |
Non-ICU treatment (n = 296) | ||||
Poor outcome at 3 months | 0.686 [0.628, 0.745] | 0.703 [0.645, 0.761] | -0.017 [-0.055, 0.021] | 0.013 |
Death during hospitalization | 0.739 [0.655, 0.822] | 0.699 [0.601, 0.798] | 0.039 [-0.024, 0.103] | 0.001 |
Death within 3 months | 0.678 [0.616, 0.739] | 0.693 [0.631, 0.756] | -0.015 [-0.056, 0.025] | 0.016 |
Non-ICU treatment and no treatment limitations (n = 178) | ||||
Poor outcome at 3 months | 0.636 [0.544; 0.729] | 0.644 [0.55; 0.737] | -0.008 [-0.07; 0.054] | 0.049 |
Death during hospitalization | - | - | - | - |
Death within 3 months | 0.647 [0.527; 0.767] | 0.597 [0.46; 0.733] | 0.051 [-0.033; 0.134] | 0.005 |