Table 1 Demographic and clinical characterization of patients per group
Variable | Group | Test statistic and p value | ES | ||
|---|---|---|---|---|---|
Grey Zone n = 63 | low Aß1-42 n = 42 | AD n = 80 | |||
Demographics | |||||
Age at diagnosis (years), median (IQR) | 71 (68–76) | 72.4 (67–79) | 72 (68–78) | H(2) = 0.450, p = 0.799 | 0.19 |
Sex (Female), n (%) | 40 (63.49%) | 19 (45.24%) | 41 (51.25%) | X2(2) = 3.827, p = 0.148 | 0.14 |
Education (years), median (IQR) | 16 (11–18) | 14.5 (12–18) | 13 (11–16) | H(2) = 2.519, p = 0.284 | 0.11 |
History of dementia in first degree relatives, n (%) | 21 (33.3%) | 21 (50%) | 31 (38.75%) | X2(2) = 1.481, p = 0.477 | 0.10 |
Medical history, n (%) | |||||
Arterial hypertension | 27 (42.9%) | 22 (52.4%) | 46 (58.2%) | X2(2) = 0.876, p = 0.645 | 0.08 |
Diabetes mellitus | 10 (15.9%) | 5 (11.9%) | 7 (8.8%) | X2(2) = 3.025, p = 0.220 | 0.17 |
Dyslipidaemia | 32 (50.8%) | 22 (52.4%) | 38 (47.5%) | X2(2) = 1.054, p = 0.591 | 0.09 |
OSAS | 4 (6.4%) | 4 (9.5%) | 4 (5.0%) | X2(2) = 1.104, p = 0.576 | 0.10 |
Smoking | 8 (12.7%) | 6 (14.29%) | 13 (16.25%) | X2(4) = 1.026, p = 0.906 | 0.10 |
Depression | 13 (20.63%) | 6 (14.28%) | 18 (22.5%) | X2(2) = 0.646, p = 0.724 | 0.07 |
Ischemic stroke/TIA | 2 (3.17%) | 5 (11.9%) | 6 (7.5%) | X2(4) = 3.307, p = 0.508 | 0.13 |
Coronary heart disease | 4 (6.35%) | 4 (9.52%) | 6 (7.5%) | X2(2) = 0.359, p = 0.836 | 0.06 |
Clinical severity, n (%) | X2(8) = 46.459, p < 0.001 | 0.38 | |||
CDR total score 0 | 28 (44.4%) | 14 (33.3%) | 0 (0%) | ||
CDR total score 0.5 | 17 (26.98%) | 11 (26.19%) | 20 (25%) | ||
CDR total score ≥ 1 | 18 (28.57%) | 17 (40.48%) | 60 (75%) | ||