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Thromboses of major arteries and ChAdOx1 nCov-19 vaccination


This correspondence discussed on published article on “thromboses of major arteries and ChAdOx1 nCov-19 vaccination”.

Dear Editor, we would like to share ideas on the publication “Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination [1].” Zarrouk and Finsterer concluded that “Both were successfully treated with intravenous immunoglobulins and non-heparin anticoagulant agents …. in case 1 and four months in case 2. [1].” Thrombosis might occur in post COVID-19 vaccination. In the present case, the pathogenesis is still unclear. A possible mechanism in the present case is hyperviscosity following vaccination [2]. This is due to rapid change of blood viscosity due to immunogenicity process of COVID-19 vaccine [2]. The successful of treatment by non-heparin anticoagulant agents can support that the main pathological problem is not on coagulation component and platelet but plasma viscosity. Additionally, when there is a decline in stimulation, a decreased blood viscosity occurs and it is concordant with the observation that the patients improved within 6 weeks.

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  1. Goereci, Y., Kleineberg, N. N., Madlener, M., Neuschmelting, H., Fink, G. R., Warnke, C., & Stetefeld, H. (2021). Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination. Neurological Research and Practice, 3(1), 52.

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  2. Joob, B., & Wiwanitkit, V. (2021). Expected viscosity after COVID-19 vaccination, hyperviscosity and previous COVID-19. Clinical and Applied Thrombosis/Hemostasis, 27, 10760296211020832.

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RM: 50% ideas, drafting, writing, final approval for submission. VW: 50% ideas, supervising, final approval for submission. Both authors read and approved the final manuscript.

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Correspondence to Rujittika Mungmunpuntipantip.

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Mungmunpuntipantip, R., Wiwanitkit, V. Thromboses of major arteries and ChAdOx1 nCov-19 vaccination. Neurol. Res. Pract. 3, 61 (2021).

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