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Table 2 Clinical course by OAT and intracranial bleeding location

From: Intracranial bleeding under vitamin K antagonists or direct oral anticoagulants: results of the RADOA registry

 

VKA-ICH

n = 32

DOAC-ICH

n = 25

p-value

VKA-SDH

n = 23

DOAC-SDH

n = 14

p-value

Bleeding after fall or likely fall

6 (18.8%)

4 (16.0%)

p = 1.0000

11 (47.8%)

8 (57.1%)

p = 0.7374

Loss of consciousness

16 (50.0%)

5 (20.0%)

p = 0.0275

5 (21.7%)

3 (21.4%)

p = 1.0000

Mechanical ventilation

13 (40.6%)

6 (24.0%)

p = 0.2597

5 (21.7%)

4 (28.6%)

p = 0.7046

Acute renal failure

0 (0.0%)

1 (4.0%)

p = 0.4386

1 (4.3%)

1 (7.1%)

p = 1.0000

Systolic BP on admission

142 ± 35.5

166 ± 48.7

p = 0.0598

145 ± 24.8

160 ± 24.3

p = 0.1714

Effective anticoagulation on admissiona

32 (100%)

21 (84.0%)

p = 0.0320

23 (100%)

12 (85.7%)

p = 0.1366

Hematoma volume (mL)

63.8 ± 59.3

20.7 ± 26.6

p = 0.0013

125 ± 58.5

69.7 ± 61.2

p = 0.0287

Small hematoma (< 30 mL)

12 (41.4%)

19 (79.2%)

p = 0.0109

0 (0.0%)

3 (30.0%)

p = 0.0410

Intraventricular hematoma

17 (60.7%)

10 (43.5%)

p = 0.2672

   

Hematoma expansion (< 24 h)

      

 No

14 (56.0%)

11 (55.0%)

p = 1.0000

13 (100%)

5 (55.6%)

p = 0.0172

 Yes

5 (20.0%)

9 (45.0%)

p = 0.0265

0 (0.0%)

4 (44.4%)

p = 0.0172

 Unknown in palliative patients

6 (24.0)

0 (0.0%)

p = 0.1071

0 (0.0%)

0 (0.0%)

p = 1.0000

Re-bleeding within 30 days (> 24 h)

      

 No

22 (95.7%)

19 (100%)

p = 1.0000

17 (89.5%)

12 (92.3%)

p = 1.0000

 Yes

0 (0.0%)

0 (0.0%)

p = 1.0000

2 (10.5%)

1 (7.7%)

p = 1.0000

 Unknown in palliative patients

1 (4.3%)

0 (0.0%)

p = 1.0000

0 (0.0%)

0 (0.0%)

p = 1.0000

PCC application

25 (78.1%)

17 (68.0%)

p = 0.5456

21 (91.3%)

11 (78.6%)

p = 0.3459

Sufficient PCC application (30-50 IE/kgKG as first application)

16 (66.7%)

12 (70.6%)

p = 1.0000

9 (45.0%)

5 (45.5%)

p = 1.0000

Operation at bleeding site

12 (46.2%)

8 (36.4%)

p = 0.5651

16 (76.2%)

7 (50.0%)

p = 0.1534

Re-operation within 30 days

2 (9.1%)

0 (0.0%)

p = 0.4902

2 (11.1%)

1 (7.7%)

p = 1.0000

30 day in-hospital mortality

12 (37.5%)

3 (12.0%)

p = 0.0374

1 (4.3%)

1 (7.1%)

p = 1.0000

Palliative care

6 (18.8%)

2 (8.0%)

p = 0.4444

0 (0.0%)

0 (0.0%)

p = 1.0000

  1. Data are presented as n (%) or mean ± SD
  2. aEffective anticoagulation was assumed if the patient had a plasma DOAC level of > 30 ng/ml and/or a last intake of < 12 h for apixaban and < 24 h for rivaroxaban and edoxaban or a phenprocoumon plasma level of > 0.2 mg/l and/or an INR > 1.3
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Neurological Research and Practice

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