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  1. We present the case of an 18 year old Caucasian with known celiac disease, who suffered a severe first attack of acute intermittent porphyria (AIP) with neuropsychiatric symptoms, severe tetraparesis and respi...

    Authors: Sebastian Nunnemann, Christoph Uibel, Petra Budig and Mathias Mäurer
    Citation: Neurological Research and Practice 2020 2:2
    Content type: Letter to the editor Published on:

  2. Antibody-mediated and paraneoplastic autoimmune encephalitides (AE) present with a broad spectrum of clinical symptoms. They often lead to progressing inflammatory changes of the central nervous system with su...

    Authors: Rosa Rössling and Harald Prüss
    Citation: Neurological Research and Practice 2020 2:1
    Content type: Standard operating procedure Published on:

  3. Autoimmune encephalitides with neural and glial antibodies have become an attractive field in neurology because the antibodies are syndrome-specific, explain the pathogenesis, indicate the likelihood of an und...

    Authors: C. G. Bien and C. I. Bien
    Citation: Neurological Research and Practice 2020 2:4
    Content type: Review Published on:

  4. Many stroke survivors suffer recurrent stroke because paroxysmal atrial fibrillation (AF) was missed and no preventive anticoagulation initiated. This prospective cohort study determined the added diagnostic y...

    Authors: Stefan Knecht, Sebastian Petsch, Paulus Kirchhof and Bettina Studer
    Citation: Neurological Research and Practice 2019 1:41
    Content type: Research article Published on:

  5. Multiple sclerosis is one of the most prevalent neurological diseases in young adults affecting over 2 million people worldwide. Alemtuzumab is a highly effective therapy in relapsing remitting MS. Alemtuzumab...

    Authors: Laura Bierhansl, Tobias Ruck, Steffen Pfeuffer, Catharina C. Gross, Heinz Wiendl and Sven G. Meuth
    Citation: Neurological Research and Practice 2019 1:40
    Content type: Clinical trial protocol Published on:

  6. Comprehensive administrative data on TIA and stroke cases and treatment modalities are fundamental for improving structural conditions and adjusting future strategies of stroke care.

    Authors: Jens Eyding, Dirk Bartig, Ralph Weber, Aristeidis H. Katsanos, Christian Weimar, Werner Hacke and Christos Krogias
    Citation: Neurological Research and Practice 2019 1:39
    Content type: Research article Published on:

  7. To date, specific therapeutic approaches to expedite recovery from apraxic deficits after left hemisphere (LH) stroke remain sparse. Thus, in this pilot study we evaluated the effect of anodal transcranial dir...

    Authors: Jana M. Ant, Eva Niessen, Elisabeth I. S. Achilles, Jochen Saliger, Hans Karbe, Peter H. Weiss and Gereon R. Fink
    Citation: Neurological Research and Practice 2019 1:38
    Content type: Research article Published on:

  8. Acute febrile neutrophilic dermatosis (Sweet‘s syndrome) is a dermatological entity, which may be associated with malignancies, drugs, and infections and which is characterized by high fever, elevated neutroph...

    Authors: Elgin Hoffmann, Christian Boßelmann, Stephan Forchhammer, Holger Lerche and Tobias Freilinger
    Citation: Neurological Research and Practice 2019 1:36
    Content type: Letter to the editor Published on:

  9. Lafora progressive myoclonus epilepsy (Lafora disease) is a rare, usually childhood-onset, fatal neurodegenerative disease caused by biallelic mutations in EPM2A (Laforin) or EPM2B (NHLRC1; Malin). The epidemiolo...

    Authors: David Brenner, Tobias Baumgartner, Sarah von Spiczak, Jan Lewerenz, Roger Weis, Anja Grimmer, Petra Gaspirova, Claudia D. Wurster, Wolfram S. Kunz, Jan Wagner, Berge A. Minassian, Christian E. Elger, Albert C. Ludolph, Saskia Biskup and Dennis Döcker
    Citation: Neurological Research and Practice 2019 1:34
    Content type: Research article Published on:

  10. The impact of stroke-related impairment on activities of daily living may vary between patients, and can only be estimated by applying patient-reported outcome measures. The International Consortium for Health...

    Authors: D. Leander Rimmele, Lisa Lebherz, Marc Frese, Hannes Appelbohm, Hans-Jürgen Bartz, Levente Kriston, Christian Gerloff, Martin Härter and Götz Thomalla
    Citation: Neurological Research and Practice 2019 1:28
    Content type: Clinical trial protocol Published on:

  11. Patients with neurological symptoms have been contributing to the increasing rates of emergency department (ED) utilization in recent years. Existing triage systems represent neurological symptoms rather crude...

    Authors: Carolin Hoyer, Patrick Stein, Hans-Werner Rausch, Angelika Alonso, Simon Nagel, Michael Platten and Kristina Szabo
    Citation: Neurological Research and Practice 2019 1:29
    Content type: Research article Published on:

  12. The regulations for fitness to drive after a cerebrovascular accident in the German Driving License Regulations (FeV) and the German Evaluation Guidelines for Driving Ability (BGL). are not up to date with the...

    Authors: Peter Marx, Gerhard Hamann, Otto Busse, Thomas Mokrusch, Hendrik Niemann, Hartmut Vatter and Bernhard Widder
    Citation: Neurological Research and Practice 2019 1:37
    Content type: Position statement Published on:

  13. Currently, no treatment that delays with the progression of Friedreich ataxia is available. In the majority of patients Friedreich ataxia is caused by homozygous pathological expansion of GAA repeats in the fi...

    Authors: Kathrin Reetz, Ralf-Dieter Hilgers, Susanne Isfort, Marc Dohmen, Claire Didszun, Kathrin Fedosov, Jennifer Kistermann, Caterina Mariotti, Alexandra Durr, Sylvia Boesch, Thomas Klopstock, Francisco Javier Rodríguez de Rivera Garrido, Ludger Schöls, Thomas Klockgether, Massimo Pandolfo, Rudolf Korinthenberg…
    Citation: Neurological Research and Practice 2019 1:33
    Content type: Clinical trial protocol Published on:

  14. Autoimmune diseases associated with antineuronal and antiglial autoantibodies (Abs) is one of the most rapidly expanding research fields in clinical neuroimmunology, with more than 30 autoantibodies described ...

    Authors: Ilya Ayzenberg, Simon Faissner, Laura Tomaske, Daniel Richter, Volker Behrendt and Ralf Gold
    Citation: Neurological Research and Practice 2019 1:32
    Content type: Review Published on:

  15. Programming deep brain stimulation in dystonia is difficult because of the delayed benefits and absence of evidence-based guidelines. Therefore, we evaluated the efficacy of a programming algorithm applied in ...

    Authors: Frank Steigerwald, Anna Dalal Kirsch, Andrea A. Kühn, Andreas Kupsch, Joerg Mueller, Wilhelm Eisner, Günther Deuschl, Daniela Falk, Alfons Schnitzler, Inger Marie Skogseid, Juliane Vollmer-Haase, Chi W. Ip, Volker Tronnier, Jan Vesper, Markus Naumann and Jens Volkmann
    Citation: Neurological Research and Practice 2019 1:25
    Content type: Research article Published on:

  16. Hereditary transthyretin amyloidosis (ATTR amyloidosis) is a rare, genetically heterogenous, and clinically variable autosomal dominant disease that severely reduces life expectancy. As treatment options grow,...

    Authors: Andreas Thimm, Saskia Bolz, Michael Fleischer, Benjamin Stolte, Sebastian Wurthmann, Andreas Totzeck, Alexander Carpinteiro, Peter Luedike, Maria Papathanasiou, Christoph Rischpler, Ken Herrmann, Tienush Rassaf, Lars Steinmüller-Magin, Christoph Kleinschnitz and Tim Hagenacker
    Citation: Neurological Research and Practice 2019 1:30
    Content type: Research article Published on:

  18. Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, a drug that inhibits viral replication. Despite antiviral...

    Authors: U. Meyding-Lamadé, C. Jacobi, F. Martinez-Torres, T. Lenhard, B. Kress, M. Kieser, C. Klose, K. Einhäupl, J. Bösel, M-B Mackert, V. Homberg, C. Koennecke, G. Weißheit, D. Claus, B. Kieseier, J. Bardutzky…
    Citation: Neurological Research and Practice 2019 1:26
    Content type: Research article Published on:

  19. Pain is highly prevalent in patients with Parkinson’s disease (PD), but underlying pathophysiological mechanisms are largely unclear. In many chronic pain syndromes deficits in endogenous pain inhibition have ...

    Authors: Wiebke Grashorn, Odette Fründt, Carsten Buhmann, Nathalie Wrobel, Katharina Schmidt and Ulrike Bingel
    Citation: Neurological Research and Practice 2019 1:27
    Content type: Research article Published on:

  20. This study focuses on genetically stratified subgroups of Parkinson’s disease patients (PD) with an enrichment of risk variants in mitochondrial genes,who might benefit from treatment with the “mitochondrial e...

    Authors: Jannik Prasuhn, Norbert Brüggemann, Nicole Hessler, Daniela Berg, Thomas Gasser, Kathrin Brockmann, Denise Olbrich, Andreas Ziegler, Inke R. König, Christine Klein and Meike Kasten
    Citation: Neurological Research and Practice 2019 1:31
    Content type: Clinical trial protocol Published on:

  21. Multiple sclerosis (MS) and human immunodeficiency virus (HIV) infection are frequent and well-studied nosological entities. Yet, comorbidity of MS and HIV has only been rarely reported in the medical literatu...

    Authors: Maria-Ioanna Stefanou, Markus Krumbholz, Ulf Ziemann and Markus C. Kowarik
    Citation: Neurological Research and Practice 2019 1:24
    Content type: Review Published on:

  22. Tools for medical image analysis have been developed to reduce the time needed to detect abnormalities and to provide more accurate results. Particularly, tools based on artificial intelligence and machine lea...

    Authors: Yahia Mokli, Johannes Pfaff, Daniel Pinto dos Santos, Christian Herweh and Simon Nagel
    Citation: Neurological Research and Practice 2019 1:23
    Content type: Review Published on:

  23. The overall prevalence of myasthenic crisis is quite low at 30/1 million inhabitants because myasthenia gravis is a rare disease per se. But it should be noted that 15–20% of patients with myasthenia gravis ex...

    Authors: Henning Stetefeld and Michael Schroeter
    Citation: Neurological Research and Practice 2019 1:19
    Content type: Standard operating procedure Published on:

  24. In the central nervous system (CNS) myelin sheaths stabilize, protect, and electrically insulate axons. However, in demyelinating autoimmune CNS diseases such as multiple sclerosis (MS) these sheaths are destr...

    Authors: Peter Göttle, Moritz Förster, Vivien Weyers, Patrick Küry, Konrad Rejdak, Hans-Peter Hartung and David Kremer
    Citation: Neurological Research and Practice 2019 1:21
    Content type: Review Published on:

  25. Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells and selective loss of neurons in the brainstem. This neurodegenerative disorder...

    Authors: Isabel Lastres-Becker, David Nonis, Joachim Nowock and Georg Auburger
    Citation: Neurological Research and Practice 2019 1:22
    Content type: Research article Published on:

  26. To evaluate outcome and toxicity of High-dose methotrexate (HDMTX)-based induction therapy followed by consolidation with conventional systemic chemotherapy and facultative intraventricular therapy (modified B...

    Authors: Sabine Seidel, Agnieszka Korfel, Thomas Kowalski, Michelle Margold, Fatme Ismail, Roland Schroers, Alexander Baraniskin, Hendrik Pels, Peter Martus and Uwe Schlegel
    Citation: Neurological Research and Practice 2019 1:17
    Content type: Research article Published on:

  27. Emerging and re-emerging viruses may cause meningitis, encephalitis, meningoencephalomyelitis, encephalitis, Guillian-Barré-like-syndromes as well as strokes. Most important viruses belong to the family of Adenov...

    Authors: Uta Meyding-Lamadé, Eva Craemer and Paul Schnitzler
    Citation: Neurological Research and Practice 2019 1:20
    Content type: Review Published on:

  28. Studies investigating the Mobile Stroke Unit (MSU) concept have shown increased thrombolysis rates, reduced alarm-to-treatment times and improved prehospital triage. Yet, so far, there is no definite scientifi...

    Authors: Peter Harmel, Martin Ebinger, Erik Freitag, Ulrike Grittner, Irina Lorenz-Meyer, Ira Napierkowski, Christian H. Nolte, Bob Siegerink and Heinrich J. Audebert
    Citation: Neurological Research and Practice 2019 1:18
    Content type: Clinical trial protocol Published on:

  29. Accurate predictors of neurological recovery after cervical spinal cord injury are needed. Particularly, to tailor adequate rehabilitation plans. However, objective and quantifiable predictors are sparse.

    Authors: Andreas Hug, Christian Schuld, Bettina Mürle, Markus Böttinger, Norbert Weidner and Rüdiger Rupp
    Citation: Neurological Research and Practice 2019 1:11
    Content type: Research article Published on:

  30. Cerebral vasculitis is a rare disorder but plays a major role in the differential diagnosis of stroke, encephalopathy and headache. This guideline was developed in order to support clinicians in the diagnosis ...

    Authors: Peter Berlit and Markus Krämer
    Citation: Neurological Research and Practice 2019 1:13
    Content type: Guidelines Published on:

  32. Aneurysmatic Subarachnoid Haemorrhage (aSAH) is typically caused by extravasated blood in the subarachnoid space due to a ruptured aneurysm. aSAH is often life-threatening in the acute stage, but may also caus...

    Authors: Oezguer A. Onur, Gereon R. Fink, Joji B. Kuramatsu and Stefan Schwab
    Citation: Neurological Research and Practice 2019 1:15
    Content type: Standard operating procedure Published on:

  33. This paper aims at reconstructing the development and role of German neurology between 1840 and 1940. Therefore a couple of original sources as well as selected material form the scattered secondary literature...

    Authors: A. Karenberg, H. Fangerau, H. Steinmetz, P. Berlit and M. Grond
    Citation: Neurological Research and Practice 2019 1:14
    Content type: Review Published on:

  34. At present, the flexible endoscopic evaluation of swallowing (FEES) is one of the most commonly used methods for the objective assessment of swallowing. This multicenter trial prospectively collected data on t...

    Authors: Rainer Dziewas, Matthias auf dem Brinke, Ulrich Birkmann, Götz Bräuer, Kolja Busch, Franziska Cerra, Renate Damm-Lunau, Juliane Dunkel, Amelie Fellgiebel, Elisabeth Garms, Jörg Glahn, Sandra Hagen, Sophie Held, Christine Helfer, Mirko Hiller, Christina Horn-Schenk…
    Citation: Neurological Research and Practice 2019 1:16
    Content type: Research article Published on:

  35. Cerebral vasculitis is a rare disorder but plays a major role in the differential diagnosis of stroke, encephalopathy and headache. This guideline was developed in order to support clinicians in the diagnosis ...

    Authors: Peter Berlit and Markus Krämer
    Citation: Neurological Research and Practice 2019 1:10
    Content type: Guidelines Published on:

  36. Impulse control disorders (ICDs) and other impulsive-compulsive related behaviours are frequent and still under recognized non-motor complications of Parkinson’s disease (PD). They result from sensitization of...

    Authors: Matthieu Béreau, Paul Krack, Norbert Brüggemann and Thomas F. Münte
    Citation: Neurological Research and Practice 2019 1:9
    Content type: Review Published on:

  37. Disadvantageous socioeconomic conditions (SEC) in both childhood and adulthood increase the risk of stroke. We investigated whether intergenerational and lifetime social advancement decreases and/or social des...

    Authors: Armin J. Grau, Annette Aigner, Christian Urbanek, Frederik Palm, Florian Buggle, Anton Safer and Heiko Becher
    Citation: Neurological Research and Practice 2019 1:8
    Content type: Research article Published on:

  39. The present study characterizes patients with the mildest of mild traumatic brain injury (TBI), as defined by a Glasgow coma score (GCS) of 15.

    Authors: Latha Ganti, Tej Stead, Yasamin Daneshvar, Aakash N. Bodhit, Christa Pulvino, Sarah W. Ayala and Keith R. Peters
    Citation: Neurological Research and Practice 2019 1:6
    Content type: Research article Published on:

  40. With the advent of modern immunotherapies for relapsing-remitting multiple sclerosis (RRMS) and the increasing amount of treatment options on the market, MS has evolved as a treatable disease. Yet, at the same...

    Authors: Ralf A. Linker and Andrew Chan
    Citation: Neurological Research and Practice 2019 1:5
    Content type: Review Published on:

  41. Mechanical thrombectomy (MT) is a new evidence-based treatment option for large vessel occlusion in the anterior brain circulation. Using comprehensive administrative data from Germany, we analysed the nationw...

    Authors: Ralph Weber, Jens Eyding, Martin Kitzrow, Dirk Bartig, Christian Weimar, Werner Hacke and Christos Krogias
    Citation: Neurological Research and Practice 2019 1:4
    Content type: Research article Published on:

  42. About 5% of all adults will have at least one epileptic seizure in their life. The incidence of all unprovoked seizures ranges from approximately 50 to 70 /100,000. The very first epileptic seizure in an adult...

    Authors: Julian Bösel
    Citation: Neurological Research and Practice 2019 1:3
    Content type: Standard operating procedure Published on:

  43. Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia. Pallidal neurostimulation is a potent alternative, but currently re...

    Authors: Thorsten M. Odorfer, Uwe Malzahn, Cordula Matthies, Peter U. Heuschmann and Jens Volkmann
    Citation: Neurological Research and Practice 2019 1:2
    Content type: Clinical trial protocol Published on:
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