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  1. The targeted use of endovascular therapy (EVT), with or without intravenous thrombolysis (IVT) in acute large cerebral vessel occlusion stroke (LVOS) has been proven to be superior compared to IVT alone. Despi...

    Authors: Philipp Ettelt, Ilko L. Maier, Marlena Schnieder, Mathias Bähr, Daniel Behme, Marios-Nikos Psychogios and Jan Liman
    Citation: Neurological Research and Practice 2020 2:29
    Content type: Research article Published on:

  2. Peripheral neuropathy represents a spectrum of diseases with different etiologies. The most common causes are diabetes, exposure to toxic substances including alcohol and chemotherapeutics, immune-mediated con...

    Authors: Helmar C. Lehmann, Gilbert Wunderlich, Gereon R. Fink and Claudia Sommer
    Citation: Neurological Research and Practice 2020 2:20
    Content type: Standard operating procedure Published on:

  3. Since January 2020, after Chinese health authorities identified a new type of coronavirus (SARS-CoV-2), the virus has spread throughout China and consecutively throughout the whole world. The most common sympt...

    Authors: Anne Lampe, Alexander Winschel, Cornelie Lang and Thorsten Steiner
    Citation: Neurological Research and Practice 2020 2:19
    Content type: Letter to the editor Published on:

  4. A brief survey among members of the German Neurorehabilitation Society aimed to document the hospital capacities (“beds”) for prolonged weaning from a mechanical ventilator for patients with neuro-disabilities...

    Authors: Thomas Platz, Andreas Bender, Christian Dohle, Anna Gorsler, Stefan Knecht, Joachim Liepert, Thomas Mokrusch and Michael Sailer
    Citation: Neurological Research and Practice 2020 2:18
    Content type: Letter to the editor Published on:

  5. Stroke is a leading cause of acquired, permanent disability worldwide. Although the treatment of acute stroke has been improved considerably, the majority of patients to date are left disabled with a considera...

    Authors: Christian Grefkes and Gereon R. Fink
    Citation: Neurological Research and Practice 2020 2:17
    Content type: Review Published on:

  6. 2019 the DGN (Deutsche Gesellschaft für Neurology) published a new guideline on the diagnosis and non-interventional therapy of neuropathic pain of any etiology excluding trigeminal neuralgia and CRPS (complex...

    Authors: Tanja Schlereth
    Citation: Neurological Research and Practice 2020 2:16
    Content type: Guidelines Published on:

  7. The study design of PIMIDES, a trial based on patient-individualized transcranial electric neurostimulation of epileptic foci, is reported. Inclusion criteria include a predominant epileptic focus and pharmaco...

    Authors: Kristina Kravalis and Andreas Schulze-Bonhage
    Citation: Neurological Research and Practice 2020 2:15
    Content type: Clinical trial protocol Published on:

  8. This paper aims to provide an overview of the use and assessment of qualitative research methods in the health sciences. Qualitative research can be defined as the study of the nature of phenomena and is especial...

    Authors: Loraine Busetto, Wolfgang Wick and Christoph Gumbinger
    Citation: Neurological Research and Practice 2020 2:14
    Content type: Review Published on:

  9. Cerebral small vessel disease (CSVD) is a disorder of brain vasculature that causes various structural changes in the brain parenchyma, and is associated with various clinical symptoms such as cognitive impair...

    Authors: A. Abdelhak, A. Huss, A. Brück, U. Sebert, B. Mayer, H. P. Müller, H. Tumani, M. Otto, D. Yilmazer-Hanke, A. C. Ludolph, J. Kassubek, E. Pinkhardt and H. Neugebauer
    Citation: Neurological Research and Practice 2020 2:13
    Content type: Research article Published on:

  10. About 6.2 million adults in Germany cannot read and write properly despite attending school for several years. They are considered to be functional illiterates (FI). Since the ability to read and write is cruc...

    Authors: Bahram Mohammadi, Thomas F. Münte, David M. Cole, Amir Sami, Melanie Boltzmann and Jascha Rüsseler
    Citation: Neurological Research and Practice 2020 2:12
    Content type: Research article Published on:

  11. Monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor (Erenumab) or against CGRP (Eptinezumab, Fremanezumab, Galcanezumab) are new substances for the preventive treatment of migrain...

    Authors: Hans-Christoph Diener, Stefanie Förderreuther, Charly Gaul, Florian Giese, Till Hamann, Dagny Holle-Lee, Tim P. Jürgens, Katharina Kamm, Torsten Kraya, Christian Lampl, Arne May, Uwe Reuter, Armin Scheffler and Peer Tfelt-Hansen
    Citation: Neurological Research and Practice 2020 2:11
    Content type: Guideline Published on:

  12. Stroke and its long-term consequences pose major challenges for the lives of those affected and healthcare systems. Neurological rehabilitation therefore primarily attempts to improve function in order to incr...

    Authors: Gunnar Birke, Silke Wolf, Thies Ingwersen, Christian Bartling, Gabriele Bender, Alfons Meyer, Achim Nolte, Katharina Ottes, Oliver Pade, Martin Peller, Jochen Steinmetz, Christian Gerloff and Götz Thomalla
    Citation: Neurological Research and Practice 2020 2:10
    Content type: Clinical trial protocol Published on:

  13. Removal of a tracheostomy tube in critically ill neurologic patients is a difficult issue, particularly due to the high incidence of oropharyngeal dysphagia. For an objective evaluation of decannulation readin...

    Authors: Tobias Warnecke, Paul Muhle, Inga Claus, Jens B. Schröder, Bendix Labeit, Sriramya Lapa, Sonja Suntrup-Krueger and Rainer Dziewas
    Citation: Neurological Research and Practice 2020 2:9
    Content type: Research article Published on:

  14. Cerebrospinal fluid (CSF) analysis is important for detecting inflammation of the nervous system and the meninges, bleeding in the area of the subarachnoid space that may not be visualized by imaging, and the ...

    Authors: H. Tumani, H. F. Petereit, A. Gerritzen, C. C. Gross, A. Huss, S. Isenmann, S. Jesse, M. Khalil, P. Lewczuk, J. Lewerenz, F. Leypoldt, N. Melzer, S. G. Meuth, M. Otto, K. Ruprecht, E. Sindern…
    Citation: Neurological Research and Practice 2020 2:8
    Content type: Guidelines Published on:

  15. Stroke is the leading cause of acquired disability in western societies. (Motor) cognitive deficits like apraxia significantly contribute to disability after stroke, harming activities of daily living and reha...

    Authors: Nina N. Kleineberg, Monika K. Richter, Ingrid Becker, Peter H. Weiss and Gereon R. Fink
    Citation: Neurological Research and Practice 2020 2:7
    Content type: Clinical trial protocol Published on:

  17. Over the past decade increasing scientific progress in the field of autoantibody–mediated neurological diseases was achieved. Movement disorders are a frequent and often prominent feature in such diseases whic...

    Authors: Felix Gövert, Frank Leypoldt, Ralf Junker, Klaus-Peter Wandinger, Günther Deuschl, Kailash P. Bhatia and Bettina Balint
    Citation: Neurological Research and Practice 2020 2:6
    Content type: Review Published on:

  19. We present the case of an 18 year old Caucasian with known celiac disease, who suffered a severe first attack of acute intermittent porphyria (AIP) with neuropsychiatric symptoms, severe tetraparesis and respi...

    Authors: Sebastian Nunnemann, Christoph Uibel, Petra Budig and Mathias Mäurer
    Citation: Neurological Research and Practice 2020 2:2
    Content type: Letter to the editor Published on:

  20. Antibody-mediated and paraneoplastic autoimmune encephalitides (AE) present with a broad spectrum of clinical symptoms. They often lead to progressing inflammatory changes of the central nervous system with su...

    Authors: Rosa Rössling and Harald Prüss
    Citation: Neurological Research and Practice 2020 2:1
    Content type: Standard operating procedure Published on:

  21. Autoimmune encephalitides with neural and glial antibodies have become an attractive field in neurology because the antibodies are syndrome-specific, explain the pathogenesis, indicate the likelihood of an und...

    Authors: C. G. Bien and C. I. Bien
    Citation: Neurological Research and Practice 2020 2:4
    Content type: Review Published on:

  22. Many stroke survivors suffer recurrent stroke because paroxysmal atrial fibrillation (AF) was missed and no preventive anticoagulation initiated. This prospective cohort study determined the added diagnostic y...

    Authors: Stefan Knecht, Sebastian Petsch, Paulus Kirchhof and Bettina Studer
    Citation: Neurological Research and Practice 2019 1:41
    Content type: Research article Published on:

  23. Multiple sclerosis is one of the most prevalent neurological diseases in young adults affecting over 2 million people worldwide. Alemtuzumab is a highly effective therapy in relapsing remitting MS. Alemtuzumab...

    Authors: Laura Bierhansl, Tobias Ruck, Steffen Pfeuffer, Catharina C. Gross, Heinz Wiendl and Sven G. Meuth
    Citation: Neurological Research and Practice 2019 1:40
    Content type: Clinical trial protocol Published on:

  24. Comprehensive administrative data on TIA and stroke cases and treatment modalities are fundamental for improving structural conditions and adjusting future strategies of stroke care.

    Authors: Jens Eyding, Dirk Bartig, Ralph Weber, Aristeidis H. Katsanos, Christian Weimar, Werner Hacke and Christos Krogias
    Citation: Neurological Research and Practice 2019 1:39
    Content type: Research article Published on:

  25. To date, specific therapeutic approaches to expedite recovery from apraxic deficits after left hemisphere (LH) stroke remain sparse. Thus, in this pilot study we evaluated the effect of anodal transcranial dir...

    Authors: Jana M. Ant, Eva Niessen, Elisabeth I. S. Achilles, Jochen Saliger, Hans Karbe, Peter H. Weiss and Gereon R. Fink
    Citation: Neurological Research and Practice 2019 1:38
    Content type: Research article Published on:

  26. Acute febrile neutrophilic dermatosis (Sweet‘s syndrome) is a dermatological entity, which may be associated with malignancies, drugs, and infections and which is characterized by high fever, elevated neutroph...

    Authors: Elgin Hoffmann, Christian Boßelmann, Stephan Forchhammer, Holger Lerche and Tobias Freilinger
    Citation: Neurological Research and Practice 2019 1:36
    Content type: Letter to the editor Published on:

  27. Lafora progressive myoclonus epilepsy (Lafora disease) is a rare, usually childhood-onset, fatal neurodegenerative disease caused by biallelic mutations in EPM2A (Laforin) or EPM2B (NHLRC1; Malin). The epidemiolo...

    Authors: David Brenner, Tobias Baumgartner, Sarah von Spiczak, Jan Lewerenz, Roger Weis, Anja Grimmer, Petra Gaspirova, Claudia D. Wurster, Wolfram S. Kunz, Jan Wagner, Berge A. Minassian, Christian E. Elger, Albert C. Ludolph, Saskia Biskup and Dennis Döcker
    Citation: Neurological Research and Practice 2019 1:34
    Content type: Research article Published on:

  28. The impact of stroke-related impairment on activities of daily living may vary between patients, and can only be estimated by applying patient-reported outcome measures. The International Consortium for Health...

    Authors: D. Leander Rimmele, Lisa Lebherz, Marc Frese, Hannes Appelbohm, Hans-Jürgen Bartz, Levente Kriston, Christian Gerloff, Martin Härter and Götz Thomalla
    Citation: Neurological Research and Practice 2019 1:28
    Content type: Clinical trial protocol Published on:

  29. Patients with neurological symptoms have been contributing to the increasing rates of emergency department (ED) utilization in recent years. Existing triage systems represent neurological symptoms rather crude...

    Authors: Carolin Hoyer, Patrick Stein, Hans-Werner Rausch, Angelika Alonso, Simon Nagel, Michael Platten and Kristina Szabo
    Citation: Neurological Research and Practice 2019 1:29
    Content type: Research article Published on:

  30. The regulations for fitness to drive after a cerebrovascular accident in the German Driving License Regulations (FeV) and the German Evaluation Guidelines for Driving Ability (BGL). are not up to date with the...

    Authors: Peter Marx, Gerhard Hamann, Otto Busse, Thomas Mokrusch, Hendrik Niemann, Hartmut Vatter and Bernhard Widder
    Citation: Neurological Research and Practice 2019 1:37
    Content type: Position statement Published on:

  31. Currently, no treatment that delays with the progression of Friedreich ataxia is available. In the majority of patients Friedreich ataxia is caused by homozygous pathological expansion of GAA repeats in the fi...

    Authors: Kathrin Reetz, Ralf-Dieter Hilgers, Susanne Isfort, Marc Dohmen, Claire Didszun, Kathrin Fedosov, Jennifer Kistermann, Caterina Mariotti, Alexandra Durr, Sylvia Boesch, Thomas Klopstock, Francisco Javier Rodríguez de Rivera Garrido, Ludger Schöls, Thomas Klockgether, Massimo Pandolfo, Rudolf Korinthenberg…
    Citation: Neurological Research and Practice 2019 1:33
    Content type: Clinical trial protocol Published on:

  32. Autoimmune diseases associated with antineuronal and antiglial autoantibodies (Abs) is one of the most rapidly expanding research fields in clinical neuroimmunology, with more than 30 autoantibodies described ...

    Authors: Ilya Ayzenberg, Simon Faissner, Laura Tomaske, Daniel Richter, Volker Behrendt and Ralf Gold
    Citation: Neurological Research and Practice 2019 1:32
    Content type: Review Published on:

  33. Programming deep brain stimulation in dystonia is difficult because of the delayed benefits and absence of evidence-based guidelines. Therefore, we evaluated the efficacy of a programming algorithm applied in ...

    Authors: Frank Steigerwald, Anna Dalal Kirsch, Andrea A. Kühn, Andreas Kupsch, Joerg Mueller, Wilhelm Eisner, Günther Deuschl, Daniela Falk, Alfons Schnitzler, Inger Marie Skogseid, Juliane Vollmer-Haase, Chi W. Ip, Volker Tronnier, Jan Vesper, Markus Naumann and Jens Volkmann
    Citation: Neurological Research and Practice 2019 1:25
    Content type: Research article Published on:

  34. Hereditary transthyretin amyloidosis (ATTR amyloidosis) is a rare, genetically heterogenous, and clinically variable autosomal dominant disease that severely reduces life expectancy. As treatment options grow,...

    Authors: Andreas Thimm, Saskia Bolz, Michael Fleischer, Benjamin Stolte, Sebastian Wurthmann, Andreas Totzeck, Alexander Carpinteiro, Peter Luedike, Maria Papathanasiou, Christoph Rischpler, Ken Herrmann, Tienush Rassaf, Lars Steinmüller-Magin, Christoph Kleinschnitz and Tim Hagenacker
    Citation: Neurological Research and Practice 2019 1:30
    Content type: Research article Published on:

  36. Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, a drug that inhibits viral replication. Despite antiviral...

    Authors: U. Meyding-Lamadé, C. Jacobi, F. Martinez-Torres, T. Lenhard, B. Kress, M. Kieser, C. Klose, K. Einhäupl, J. Bösel, M-B Mackert, V. Homberg, C. Koennecke, G. Weißheit, D. Claus, B. Kieseier, J. Bardutzky…
    Citation: Neurological Research and Practice 2019 1:26
    Content type: Research article Published on:

  37. Pain is highly prevalent in patients with Parkinson’s disease (PD), but underlying pathophysiological mechanisms are largely unclear. In many chronic pain syndromes deficits in endogenous pain inhibition have ...

    Authors: Wiebke Grashorn, Odette Fründt, Carsten Buhmann, Nathalie Wrobel, Katharina Schmidt and Ulrike Bingel
    Citation: Neurological Research and Practice 2019 1:27
    Content type: Research article Published on:

  38. This study focuses on genetically stratified subgroups of Parkinson’s disease patients (PD) with an enrichment of risk variants in mitochondrial genes,who might benefit from treatment with the “mitochondrial e...

    Authors: Jannik Prasuhn, Norbert Brüggemann, Nicole Hessler, Daniela Berg, Thomas Gasser, Kathrin Brockmann, Denise Olbrich, Andreas Ziegler, Inke R. König, Christine Klein and Meike Kasten
    Citation: Neurological Research and Practice 2019 1:31
    Content type: Clinical trial protocol Published on:

  39. Multiple sclerosis (MS) and human immunodeficiency virus (HIV) infection are frequent and well-studied nosological entities. Yet, comorbidity of MS and HIV has only been rarely reported in the medical literatu...

    Authors: Maria-Ioanna Stefanou, Markus Krumbholz, Ulf Ziemann and Markus C. Kowarik
    Citation: Neurological Research and Practice 2019 1:24
    Content type: Review Published on:

  40. Tools for medical image analysis have been developed to reduce the time needed to detect abnormalities and to provide more accurate results. Particularly, tools based on artificial intelligence and machine lea...

    Authors: Yahia Mokli, Johannes Pfaff, Daniel Pinto dos Santos, Christian Herweh and Simon Nagel
    Citation: Neurological Research and Practice 2019 1:23
    Content type: Review Published on:

  41. The overall prevalence of myasthenic crisis is quite low at 30/1 million inhabitants because myasthenia gravis is a rare disease per se. But it should be noted that 15–20% of patients with myasthenia gravis ex...

    Authors: Henning Stetefeld and Michael Schroeter
    Citation: Neurological Research and Practice 2019 1:19
    Content type: Standard operating procedure Published on:

  42. In the central nervous system (CNS) myelin sheaths stabilize, protect, and electrically insulate axons. However, in demyelinating autoimmune CNS diseases such as multiple sclerosis (MS) these sheaths are destr...

    Authors: Peter Göttle, Moritz Förster, Vivien Weyers, Patrick Küry, Konrad Rejdak, Hans-Peter Hartung and David Kremer
    Citation: Neurological Research and Practice 2019 1:21
    Content type: Review Published on:

  43. Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells and selective loss of neurons in the brainstem. This neurodegenerative disorder...

    Authors: Isabel Lastres-Becker, David Nonis, Joachim Nowock and Georg Auburger
    Citation: Neurological Research and Practice 2019 1:22
    Content type: Research article Published on:

  44. To evaluate outcome and toxicity of High-dose methotrexate (HDMTX)-based induction therapy followed by consolidation with conventional systemic chemotherapy and facultative intraventricular therapy (modified B...

    Authors: Sabine Seidel, Agnieszka Korfel, Thomas Kowalski, Michelle Margold, Fatme Ismail, Roland Schroers, Alexander Baraniskin, Hendrik Pels, Peter Martus and Uwe Schlegel
    Citation: Neurological Research and Practice 2019 1:17
    Content type: Research article Published on:

  45. Emerging and re-emerging viruses may cause meningitis, encephalitis, meningoencephalomyelitis, encephalitis, Guillian-Barré-like-syndromes as well as strokes. Most important viruses belong to the family of Adenov...

    Authors: Uta Meyding-Lamadé, Eva Craemer and Paul Schnitzler
    Citation: Neurological Research and Practice 2019 1:20
    Content type: Review Published on:

  46. Studies investigating the Mobile Stroke Unit (MSU) concept have shown increased thrombolysis rates, reduced alarm-to-treatment times and improved prehospital triage. Yet, so far, there is no definite scientifi...

    Authors: Peter Harmel, Martin Ebinger, Erik Freitag, Ulrike Grittner, Irina Lorenz-Meyer, Ira Napierkowski, Christian H. Nolte, Bob Siegerink and Heinrich J. Audebert
    Citation: Neurological Research and Practice 2019 1:18
    Content type: Clinical trial protocol Published on:

  47. Accurate predictors of neurological recovery after cervical spinal cord injury are needed. Particularly, to tailor adequate rehabilitation plans. However, objective and quantifiable predictors are sparse.

    Authors: Andreas Hug, Christian Schuld, Bettina Mürle, Markus Böttinger, Norbert Weidner and Rüdiger Rupp
    Citation: Neurological Research and Practice 2019 1:11
    Content type: Research article Published on:

  48. Cerebral vasculitis is a rare disorder but plays a major role in the differential diagnosis of stroke, encephalopathy and headache. This guideline was developed in order to support clinicians in the diagnosis ...

    Authors: Peter Berlit and Markus Krämer
    Citation: Neurological Research and Practice 2019 1:13
    Content type: Guidelines Published on:

  50. Aneurysmatic Subarachnoid Haemorrhage (aSAH) is typically caused by extravasated blood in the subarachnoid space due to a ruptured aneurysm. aSAH is often life-threatening in the acute stage, but may also caus...

    Authors: Oezguer A. Onur, Gereon R. Fink, Joji B. Kuramatsu and Stefan Schwab
    Citation: Neurological Research and Practice 2019 1:15
    Content type: Standard operating procedure Published on:
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