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  1. The modified Boston criteria (mBC) define the probability for the diagnosis of cerebral amyloid angiopathy (CAA). Its initial clinical presentation differs from asymptomatic cerebral microbleedings (cMBs), acu...

    Authors: Andrea Wagner, Christiane Groetsch, Sibylle Wilfling, Karl-Michael Schebesch, Mustafa Kilic, Marjan Nenkov, Christina Wendl, Ralf A. Linker and Felix Schlachetzki
    Citation: Neurological Research and Practice 2021 3:51
    Content type: Research article Published on:

  2. Thrombus histology has become a potential diagnostic tool for the etiology assessment of patients with ischemic stroke caused by embolic proximal vessel occlusion. We validated a classification rule that diffe...

    Authors: Julika Ribbat-Idel, Florian Stellmacher, Florian Jann, Nicolas Kalms, Inke R. König, Marcus Ohlrich, Georg Royl, Stefan Klotz, Thomas Kurz, Andrè Kemmling and Florian C. Roessler
    Citation: Neurological Research and Practice 2021 3:50
    Content type: Research article Published on:

  3. More patients with left-hemispheric than right-hemispheric strokes are admitted to hospitals. This is due to the easier recognition of cortical symptoms of the dominant-hemisphere. The thalamus constitutes a “...

    Authors: Martin A. Schaller-Paule, Ariane Martinez Oeckel, Jan-Rüdiger Schüre, Fee Keil, Elke Hattingen, Christian Foerch and Maximilian Rauch
    Citation: Neurological Research and Practice 2021 3:49
    Content type: Research article Published on:

  5. Post stroke management has moved into the focus as it represents the only way to secure acute treatment effects in the long term. Due to individual courses, post stroke management appears rather challenging an...

    Authors: Dominik Michalski, Alexander Prost, Till Handel, Max Schreiber, Jean-Baptiste Tylcz, Daniela Geisler, Daniela Urban, Stephanie Schramm, Stefan Lippmann, Jenny Gullnick, Thomas Neumuth, Joseph Classen and Galina Ivanova
    Citation: Neurological Research and Practice 2021 3:53
    Content type: Clinical trial protocol Published on:

    The Commentary to this article has been published in Neurological Research and Practice 2021 3:54

  6. Measures taking aim at minimizing the risk of coronavirus transmission and fear of infection may affect decisions to seek care for other medical emergency conditions. The purpose of this analysis was to analyz...

    Authors: Johannes A. R. Pfaff, Marcial E. Harlan, Günter Pfaff, Alexander Hubert and Martin Bendszus
    Citation: Neurological Research and Practice 2021 3:47
    Content type: Research article Published on:

  7. We aimed to identify groups of patients with similar health status after stroke, assessed by patient reported outcome measures (PROMs), to improve initial risk stratification.

    Authors: D. Leander Rimmele, Theresa Schrage, Lisa Lebherz, Levente Kriston, Christian Gerloff, Martin Härter and Götz Thomalla
    Citation: Neurological Research and Practice 2021 3:43
    Content type: Research article Published on:

  8. Since the coronavirus disease 2019 (COVID-19) has risen, several risk factors have been identified, predicting a worse outcome. It has been speculated that patients with Multiple sclerosis (MS) have an increas...

    Authors: Daniel Richter, Simon Faissner, Dirk Bartig, Lars Tönges, Kerstin Hellwig, Ilya Ayzenberg, Christos Krogias and Ralf Gold
    Citation: Neurological Research and Practice 2021 3:42
    Content type: Research article Published on:

  9. To prospectively analyze factors associated with detecting epileptogenic lesions on MRI within the work-sharing process of neurologists, epileptologists, radiologists and neuroradiologists.

    Authors: Tim Wehner, Philippe Weckesser, Steven Schulz, Annika Kowoll, Sebastian Fischer, Jessica Bosch, Leonie Weinhold, Rolf Fimmers, Matthias Schmid and Jörg Wellmer
    Citation: Neurological Research and Practice 2021 3:41
    Content type: Research article Published on:

  11. Authors: A. Bayas, A. Berthele, B. Hemmer, C. Warnke and B. Wildemann
    Citation: Neurological Research and Practice 2021 3:45
    Content type: Review Published on:

    The Commentary to this article has been published in Neurological Research and Practice 2021 3:46

  13. Stroke patients with large vessel occlusion (LVO) require endovascular therapy (EVT) provided by comprehensive stroke centers (CSC). One strategy to achieve fast stroke symptom ‘onset to treatment’ times (OTT)...

    Authors: Erendira G. Boss, Ferdinand O. Bohmann, Björn Misselwitz, Manfred Kaps, Tobias Neumann-Haefelin, Waltraud Pfeilschifter and Natalia Kurka
    Citation: Neurological Research and Practice 2021 3:38
    Content type: Research article Published on:

  15. Treatment of acute stroke performed by a multiprofessional, interdisciplinary team is highly time dependent. Interface problems are preprogrammed and pitfalls relevant to patient safety are omnipresent. The Sa...

    Authors: Ferdinand O. Bohmann, Joachim Guenther, Katharina Gruber, Tanja Manser, Helmuth Steinmetz and Waltraud Pfeilschifter
    Citation: Neurological Research and Practice 2021 3:37
    Content type: Research article Published on:

  16. A 53-year old male with a history of progressive visual impairment, hearing loss, peripheral neuropathy, poorly controlled diabetes mellitus, cardiomyopathy, and weight loss was referred to the rare disease ce...

    Authors: Tim W. Rattay, Torsten Kluba and Ludger Schöls
    Citation: Neurological Research and Practice 2021 3:40
    Content type: Letter to the editor Published on:

  17. The current Libyan civil war has originated many casualties, imposing medical challenges. War injuries are complex, requiring specialized knowledge and interdisciplinary assessment for adequate patient and int...

    Authors: Felix Dootz, Otto-Magnus von Stackelberg, Joan Abaya, Christian Jacobi, Christoph Mohs, Eva Maria Craemer, Christoph Rangger, Uta Meyding-Lamadé and Eva Kathrin Lamadé
    Citation: Neurological Research and Practice 2021 3:36
    Content type: Research article Published on:

  18. Tuberous sclerosis complex (TSC) is a monogenetic, multisystemic disease characterised by the formation of benign tumours that can affect almost all organs, caused by pathogenic variations in TSC1 or TSC2. In thi...

    Authors: Johann Philipp Zöllner, Nadine Conradi, Matthias Sauter, Markus Knuf, Susanne Knake, Gerhard Kurlemann, Thomas Mayer, Christoph Hertzberg, Astrid Bertsche, Ilka Immisch, Karl Martin Klein, Klaus Marquard, Sascha Meyer, Anna H. Noda, Felix von Podewils, Hannah Schäfer…
    Citation: Neurological Research and Practice 2021 3:35
    Content type: Research article Published on:

  19. Neurological long-term sequelae are increasingly considered an important challenge in the recent COVID-19 pandemic. However, most evidence for neurological symptoms after SARS-CoV-2 infection and central nervo...

    Authors: Max Borsche, Dirk Reichel, Anja Fellbrich, Anne S. Lixenfeld, Johann Rahmöller, Eva-Juliane Vollstedt, Bandik Föh, Alexander Balck, Christine Klein, Marc Ehlers and Andreas Moser
    Citation: Neurological Research and Practice 2021 3:34
    Content type: Letter to the editor Published on:

  20. Optic nerve ultrasound is an established routine supplementary diagnostic tool for idiopathic intracranial pressure but it can also be helpful in avoiding misdiagnoses. We describe a case of an obese 15- year-...

    Authors: Eleni Bakola, Dimitrios Alonistiotis, Chryssa Arvaniti, Stavroula Salakou, Niki Nana, Aikaterini Foska, Vasiliki Kotsali-Peteinelli, Konstantinos Voumvourakis and Georgios Tsivgoulis
    Citation: Neurological Research and Practice 2021 3:33
    Content type: Letter to the editor Published on:

  21. To analyse nationwide changes in neurointerventional center size of all German hospitals performing mechanical thrombectomy (MT) in stroke patients from 2016 to 2019. Furthermore, we assessed cross-district pa...

    Authors: Ralph Weber, Dirk Bartig, Christos Krogias, Daniel Richter, Werner Hacke and Jens Eyding
    Citation: Neurological Research and Practice 2021 3:32
    Content type: Letter to the editor Published on:

  22. The prehospital identification of stroke patients with large-vessel occlusion (LVO), that should be immediately transported to a thrombectomy capable centre is an unsolved problem. Our aim was to determine whe...

    Authors: Stefanie Behnke, Thomas Schlechtriemen, Andreas Binder, Monika Bachhuber, Mark Becker, Benedikt Trauth, Martin Lesmeister, Elmar Spüntrup, Silke Walter, Lukas Hoor, Andreas Ragoschke-Schumm, Fatma Merzou, Luca Tarantini, Thomas Bertsch, Jürgen Guldner, Achim Magull-Seltenreich…
    Citation: Neurological Research and Practice 2021 3:31
    Content type: Research article Published on:

  24. Anti-glial nuclear antibody (AGNA) is an onconeuroal antibody targeting the nuclei of Bergmann glia in the cerebellum and Anti-SRY-related HMG-box 1 (SOX1). It is highly specific for small cell lung cancer (SC...

    Authors: Jonas Feldheim, Cornelius Deuschl, Martin Glas, Christoph Kleinschnitz and Tim Hagenacker
    Citation: Neurological Research and Practice 2021 3:30
    Content type: Letter to the editor Published on:

  25. Oral administration of N,N-Dimethylglycine (DMG), a tertiary amino acid, presumably enhances oxygen utilization by tissue and complex with free radicals. Beneficial effects are improved endurance performance a...

    Authors: Thomas Wolfsegger, Klaus Böck, Wolfgang Schimetta, Tim J. von Oertzen and Hamid Assar
    Citation: Neurological Research and Practice 2021 3:29
    Content type: Letter to the editor Published on:

  26. Cerebral venous sinus thrombosis (CVST) can infrequently lead to chronical intracranial hypertension (IH) due to the altered venous drainage. The aim of this study was to ascertain the risk of IH after CVST an...

    Authors: Christina Geisbüsch, Christian Herweh, Christoph Gumbinger, Peter A. Ringleb, Markus A. Möhlenbruch and Simon Nagel
    Citation: Neurological Research and Practice 2021 3:28
    Content type: Research article Published on:

  27. Emergency intubation is an inherent risk of procedural sedation regimens for endovascular treatment (EVT) of acute ischemic stroke. We aimed to characterize the subgroup of patients, who had to be emergently i...

    Authors: Min Chen, Dorothea Kronsteiner, Johannes A. R. Pfaff, Simon Schieber, Martin Bendszus, Meinhard Kieser, Wolfgang Wick, Markus A. Möhlenbruch, Peter A. Ringleb, Julian Bösel and Silvia Schönenberger
    Citation: Neurological Research and Practice 2021 3:27
    Content type: Research article Published on:

  28. Removal of a tracheostomy tube in critically ill neurologic patients is a critical issue during intensive care treatment, particularly due to severe dysphagia and insufficient airway protection. The “Standardi...

    Authors: Paul Muhle, Sonja Suntrup-Krueger, Karoline Burkardt, Sriramya Lapa, Mao Ogawa, Inga Claus, Bendix Labeit, Sigrid Ahring, Stephan Oelenberg, Tobias Warnecke and Rainer Dziewas
    Citation: Neurological Research and Practice 2021 3:26
    Content type: Research article Published on:

  29. All-trans retinoic acid (ATRA) is an acid derivative of vitamin A which is discussed as a promising candidate to ameliorate the disease course of multiple sclerosis (MS) by immunomodulation or even by promoting r...

    Authors: Christoph Ruschil, Evelyn Dubois, Maria-Ioanna Stefanou, Markus Christian Kowarik, Ulf Ziemann, Marcus Schittenhelm, Markus Krumbholz and Felix Bischof
    Citation: Neurological Research and Practice 2021 3:25
    Content type: Research article Published on:

  30. Neurogenic dysphagia defines swallowing disorders caused by diseases of the central and peripheral nervous system, neuromuscular transmission, or muscles. Neurogenic dysphagia is one of the most common and at ...

    Authors: Rainer Dziewas, Hans-Dieter Allescher, Ilia Aroyo, Gudrun Bartolome, Ulrike Beilenhoff, Jörg Bohlender, Helga Breitbach-Snowdon, Klemens Fheodoroff, Jörg Glahn, Hans-Jürgen Heppner, Karl Hörmann, Christian Ledl, Christoph Lücking, Peter Pokieser, Joerg C. Schefold, Heidrun Schröter-Morasch…
    Citation: Neurological Research and Practice 2021 3:23
    Content type: Guidelines Published on:

  31. Approximately half of patients with spontaneous intracerebral hemorrhage (ICH) die within 1 year. Prognostication in this context is of great importance, to guide goals of care discussions, clinical decision-m...

    Authors: Jens Witsch, Bob Siegerink, Christian H. Nolte, Maximilian Sprügel, Thorsten Steiner, Matthias Endres and Hagen B. Huttner
    Citation: Neurological Research and Practice 2021 3:22
    Content type: Review Published on:

  32. Cervical artery dissection (CAD) is a rare cause of acute ischemic stroke (AIS) with large vessel occlusion (LVO) and may constitute a challenge for mechanical thrombectomy (MT). We compared procedural charact...

    Authors: Ludwig Schlemm, Regina von Rennenberg, Eberhard Siebert, Georg Bohner, Fabian Flottmann, Gabor C. Petzold, Götz Thomalla, Matthias Endres and Christian H. Nolte
    Citation: Neurological Research and Practice 2021 3:20
    Content type: Research article Published on:

  33. Transient ischemic attack (TIA) is considered to be an important risk factor for the development of ischemic stroke and requires complete etiopathogenic evaluation and prompt initiation of secondary prevention...

    Authors: Lina Palaiodimou, Aikaterini Theodorou, Stefanos Lachanis, George P. Paraskevas, Matilda Papathanasiou, Christina Zompola, Konstantinos I. Voumvourakis and Georgios Tsivgoulis
    Citation: Neurological Research and Practice 2021 3:19
    Content type: Letter to the editor Published on:

  34. Results of randomized controlled trials (RCT) do not provide definite guidance for secondary prevention after ischemic stroke (IS)/transient ischemic attack (TIA) attributed to patent foramen ovale (PFO). No r...

    Authors: Sven Poli, Elisabeth Siebert, Joshua Mbroh, Khouloud Poli, Markus Krumbholz, Annerose Mengel, Simon Greulich, Florian Härtig, Karin A. L. Müller, Wolfgang Bocksch, Meinrad Gawaz, Ulf Ziemann and Christine S. Zuern
    Citation: Neurological Research and Practice 2021 3:16
    Content type: Research article Published on:

  35. Stroke Unit Care (SUC), intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are evidence-based treatment options for acute ischemic stroke (AIS). Using nationwide comprehensive administrative data ...

    Authors: Daniel Richter, Ralph Weber, Jens Eyding, Dirk Bartig, Björn Misselwitz, Armin Grau, Werner Hacke and Christos Krogias
    Citation: Neurological Research and Practice 2021 3:14
    Content type: Research article Published on:

  36. We report on a case of a 52-year-old male with sudden paraparesis. The initial MRI showed contrast enhancement of the conus medullaris and the complete cauda equina. Follow-up MRI revealed a spinal ischemia in...

    Authors: Benedict Breitling, Frederic Carsten Schmeel, Alexander Radbruch and Oliver Kaut
    Citation: Neurological Research and Practice 2021 3:13
    Content type: Letter to the editor Published on:

  37. COVID-19 pandemic caused a decline in stroke care in several countries. The objective was to describe lockdown stroke care in a tertiary stroke center in Düsseldorf, Germany near Heinsberg, a German hot spot f...

    Authors: Robin Jansen, John-Ih Lee, Bernd Turowski, Marius Kaschner, Julian Caspers, Michael Bernhard, Hans-Peter Hartung, Sebastian Jander, Tobias Ruck, Sven G. Meuth and Michael Gliem
    Citation: Neurological Research and Practice 2021 3:21
    Content type: Research article Published on:

  38. Since the outbreak of coronavirus disease 2019 (COVID-19), a growing number of cases of acute transverse myelitis associated with COVID-19 have been reported. Here, we present the case of a patient who develop...

    Authors: Ji-Won Kim, Nuran Abdullayev, Janina Neuneier, Gereon R. Fink and Helmar C. Lehmann
    Citation: Neurological Research and Practice 2021 3:18
    Content type: Letter to the editor Published on:

  39. The SARS-Coronavirus-2 (SARS-CoV-2) invades the respiratory system, causing acute and sometimes severe pulmonary symptoms, but turned out to also act multisystematically with substantial impact on the brain. A...

    Authors: Ummehan Ermis, Marcus Immanuel Rust, Julia Bungenberg, Ana Costa, Michael Dreher, Paul Balfanz, Gernot Marx, Martin Wiesmann, Kathrin Reetz, Simone C. Tauber and Jörg B. Schulz
    Citation: Neurological Research and Practice 2021 3:17
    Content type: Research article Published on:

  40. Insomnia is defined as difficulties of initiating and maintaining sleep, early awakening and poor subjective sleep quality despite adequate opportunity and circumstances for sleep with impairment of daytime pe...

    Authors: Geert Mayer, Svenja Happe, Stefan Evers, Wiebke Hermann, Sabine Jansen, Ulf Kallweit, Maria-Lucia Muntean, Dieter Pöhlau, Dieter Riemann, Michael Saletu, Melanie Schichl, Wolfgang J. Schmitt, Friederike Sixel-Döring and Peter Young
    Citation: Neurological Research and Practice 2021 3:15
    Content type: Guidelines Published on:

  41. Delirium is a frequent complication in hospitalised patients, often leading to difficulties in patient management and is associated with increased morbidity and mortality. Most patients in intensive care units...

    Authors: Juraj Kukolja and Jens Kuhn
    Citation: Neurological Research and Practice 2021 3:12
    Content type: Standard operating procedure Published on:

  42. Computed tomography angiography (CTA) of the head and neck during acute ischemic stroke (AIS) usually includes visualization of lung apices. The possibility to evaluate for pulmonary changes, e.g. peripheral g...

    Authors: Johannes A. R. Pfaff, Bianka Füssel, Marcial E. Harlan, Alexander Hubert and Martin Bendszus
    Citation: Neurological Research and Practice 2021 3:10
    Content type: Research article Published on:

  43. Vestibular schwannomas (VS) are benign slow growing tumors arising from the vestibular nerve. The role of cyclooxygenase 2 (COX2) in tumor development of growth has been addressed in a few studies with contrad...

    Authors: Felix Behling, Elisa Suhm, Vanessa Ries, Vítor Moura Gonçalves, Ghazaleh Tabatabai, Marcos Tatagiba and Jens Schittenhelm
    Citation: Neurological Research and Practice 2021 3:11
    Content type: Research article Published on:

  44. Direct oral anticoagulants (DOAC) including edoxaban are increasingly used for stroke prevention in atrial fibrillation. Despite treatment, annual stroke rate in these patients remains 1–2%. Rapid assessment o...

    Authors: Florian Härtig, Ingvild Birschmann, Andreas Peter, Sebastian Hörber, Matthias Ebner, Matthias Sonnleitner, Charlotte Spencer, Paula Bombach, Maria-Ioanna Stefanou, Johannes Tünnerhoff, Annerose Mengel, Joachim Kuhn, Ulf Ziemann and Sven Poli
    Citation: Neurological Research and Practice 2021 3:9
    Content type: Research article Published on:

  45. Up to 2/3rd of the stroke subjects may experience impairment in any of the somatosensory modalities such as light touch, proprioception, and stereognosis. The sensory recovery is strongly associated with the l...

    Authors: Kamal Narayan Arya, Shanta Pandian, G. G. Agarwal, Neera Chaudhary and Akshay Kumar Joshi
    Citation: Neurological Research and Practice 2021 3:8
    Content type: Clinical trial protocol Published on:

  46. Stroke has a long-term impact on functional status and quality of life in multiple health domains. A well-coordinated managed care program for stroke patients is crucial for ameliorating patients’ health and c...

    Authors: David Leander Rimmele, Theresa Schrage, Christian Brettschneider, Alexander Engels, Christian Gerloff, Martin Härter, Michael Rosenkranz, Holger Schmidt, Levente Kriston and Götz Thomalla
    Citation: Neurological Research and Practice 2021 3:7
    Content type: Clinical trial protocol Published on:

  47. Medical progress, economization of healthcare systems, and scarcity of resources raise fundamental ethical issues. Physicians are exposed to increasing moral conflict situations, which may cause Moral Distress...

    Authors: Hanna Hildesheim, Annette Rogge, Christoph Borzikowsky, Victoria Dorothea Witt, Eva Schäffer and Daniela Berg
    Citation: Neurological Research and Practice 2021 3:6
    Content type: Research article Published on:

  49. Safety data of intravenous thrombolysis (IVT) in presence of aortic arch thrombus is scant. Furthermore, IVT is debatable in patients with prior recent stroke. We present a 51-year-old woman with recurrent maj...

    Authors: Ioanna Koutroulou, Georgios Tsivgoulis, Vasileios Rafailidis, Elissavet Psoma, Konstantinos Kouskouras, Panagiotis Fotiadis, Nikolaos Grigoriadis and Theodoros Karapanayiotides
    Citation: Neurological Research and Practice 2021 3:4
    Content type: Letter to the editor Published on:
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