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  1. Here we report on a patient with Parkinson's Disease and camptocormia due to Myofibrillar Myopathy Type 3. By leading the reader through the clinical reasoning process and highlighting the respective red flags...

    Authors: Jan Niklas Petry-Schmelzer, Angela Abicht, Michael T. Barbe and Gilbert Wunderlich
    Citation: Neurological Research and Practice 2023 5:26
    Content type: Letter to the editor Published on:

  2. Patients with Parkinson’s Disease (PD) require an all-encompassing and individualized care including pharmacological as well as non-pharmacological treatment approaches, such as physical therapy, occupational ...

    Authors: Katharina Achtert, Tessa Huchtemann, Maria Altendorf, Linda Kerkemeyer, Malte Haring, Carina Lummer, Lena Frenz, Theresa Becking, Jonas Friedmann, Philip Mildner, Katharina Schwarze, Lars Steinhaus, Volker Amelung and Tobias Warnecke
    Citation: Neurological Research and Practice 2023 5:23
    Content type: Clinical trial protocol Published on:

  3. About 25% of all ischaemic strokes are related to cardio-embolism, most often due to atrial fibrillation (AF). Little is known about the extent and standardization of routine cardiac diagnostic work-up at cert...

    Authors: Manuel C. Olma, Serdar Tütüncü, Ulrike Grittner, Claudia Kunze, Muhammad Jawad-Ul-Qamar, Paulus Kirchhof, Joachim Röther, Götz Thomalla, Roland Veltkamp, Ulrich Laufs, Darius G. Nabavi, Peter U. Heuschmann, Matthias Endres and Karl Georg Haeusler
    Citation: Neurological Research and Practice 2023 5:21
    Content type: Research article Published on:

  4. Large vessel occlusion (LVO) is a severe condition that carries a high risk of morbidity and mortality, underscoring the importance of effective prevention strategies. This retrospective study aimed to analyze...

    Authors: Konstantin Kohlhase, Jan Hendrik Schäfer, Lisa Marie Tako, Laurent M. Willems, Elke Hattingen, Ferdinand O. Bohmann, Christian Grefkes, Felix Rosenow and Adam Strzelczyk
    Citation: Neurological Research and Practice 2023 5:22
    Content type: Research article Published on:

  5. Discontinuing anti-seizure medication (ASM) should be considered in persons with epilepsy with long-term seizure freedom. Clinicians should also pursue ASM withdrawal in persons with one-time seizures without ...

    Authors: Laurien K. L. Dhaenens-Meyer, Elisabeth Schriewer, Yvonne G. Weber and Stefan Wolking
    Citation: Neurological Research and Practice 2023 5:20
    Content type: Research article Published on:

  6. Groundbreaking study results since 2014 have dramatically changed the therapeutic options in acute therapy for severe ischemic stroke caused by large vessel occlusion (LVO). The scientifically proven advances ...

    Authors: Julian Bösel, Gordian J. Hubert, Jessica Jesser, Markus A. Möhlenbruch and Peter A. Ringleb
    Citation: Neurological Research and Practice 2023 5:19
    Content type: Standard operating procedure Published on:

  7. Motor impairments are the objectively most striking sequelae after stroke, but non-motor consequences represent a high burden for stroke survivors as well. Depression is reported in one third of patients, the ...

    Authors: Frederike A. Straeten, Stephanie van Zyl, Bastian Maus, Jochen Bauer, Heiner Raum, Catharina C. Gross, Sabine Bruchmann, Nils C. Landmeyer, Cornelius Faber, Jens Minnerup and Antje Schmidt-Pogoda
    Citation: Neurological Research and Practice 2023 5:18
    Content type: Clinical trial protocol Published on:

  8. Unpredictable vegetative deteriorations made the treatment of patients with acute COVID-19 on intensive care unit particularly challenging during the first waves of the pandemic. Clinical correlates of dysauto...

    Authors: Marcel Seungsu Woo, Christina Mayer, Marlene Fischer, Stefan Kluge, Kevin Roedl, Christian Gerloff, Patrick Czorlich, Götz Thomalla, Julian Schulze zur Wiesch and Nils Schweingruber
    Citation: Neurological Research and Practice 2023 5:17
    Content type: Research article Published on:

  10. In 2022 the DGN (Deutsche Gesellschaft für Neurologie) published an updated Transient Global Amnesia (TGA) guideline. TGA is characterized by a sudden onset of retrograde and anterograde amnesia for a period o...

    Authors: Dirk Sander, Thorsten Bartsch, Florian Connolly, Christian Enzinger, Urs Fischer, Nils Nellesen, Holger Poppert, Kristina Szabo and Helge Topka
    Citation: Neurological Research and Practice 2023 5:15
    Content type: Guidelines Published on:

  11. Epidural electrical epinal cord stimulation (ESCS) is an established therapeutic option in various chronic pain conditions. In the last decade, proof-of-concept studies have demonstrated that ESCS in combinati...

    Authors: Antonia Luz, Rüdiger Rupp, Rezvan Ahmadi and Norbert Weidner
    Citation: Neurological Research and Practice 2023 5:14
    Content type: Review Published on:

  12. Infective endocarditis (IE) is a serious condition with a high mortality, represents a rare cause of stroke and an increased risk of intracranial hemorrhage. In this single center study, we characterize stroke...

    Authors: L. Nitsch, O. Shirvani Samani, M. Silaschi, M. Schafigh, S. Zimmer, G. C. Petzold, C. Kindler and F. J. Bode
    Citation: Neurological Research and Practice 2023 5:13
    Content type: Research article Published on:

  13. The relationship between presenting blood pressure in acute ischemic stroke patients and outcome is complex. Several studies have demonstrated a U-shaped curve with worse outcomes when blood pressure is high o...

    Authors: Michael De Georgia, Theodore Bowen, K. Rose Duncan and Alex Bou Chebl
    Citation: Neurological Research and Practice 2023 5:12
    Content type: Review Published on:

  17. Treatment of relapsed or refractory primary CNS lymphoma (r/r PCNSL) is difficult, particularly in patients not eligible for high dose chemotherapy with autologous stem cell transplantation (HDC-ASCT). No stan...

    Authors: Sabine Seidel, Thomas Kowalski, Verena Nilius-Eliliwi, Roland Schroers and Uwe Schlegel
    Citation: Neurological Research and Practice 2023 5:8
    Content type: Research article Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:16

  18. Post-stroke dysphagia (PSD) is common and can lead to serious complications. Pharyngeal sensory impairment is assumed to contribute to PSD. The aim of this study was to investigate the relationship between PSD...

    Authors: Bendix Labeit, Anne Jung, Sigrid Ahring, Stephan Oelenberg, Paul Muhle, Malte Roderigo, Fiona Wenninger, Jonas von Itter, Inga Claus, Tobias Warnecke, Rainer Dziewas and Sonja Suntrup-Krueger
    Citation: Neurological Research and Practice 2023 5:7
    Content type: Research article Published on:

  19. Regional deprivation has been shown to be an influential factor in stroke incidence risk. However, there is a paucity of knowledge on regional differences in stroke incidence and mortality in Germany.

    Authors: Matthias Hans Belau, Heiko Becher, Maya Riefflin, Dirk Bartig, Lars Schwettmann, Christopher Jan Schwarzbach and Armin Grau
    Citation: Neurological Research and Practice 2023 5:6
    Content type: Research article Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:16

  20. Spontaneous intracerebral hemorrhage (ICH) is a devastating type of stroke with a huge impact on patients and families. Expanded use of oral anticoagulants and ageing population might contribute to an epidemio...

    Authors: Ludovica De Rosa, Renzo Manara, Francesca Vodret, Caterina Kulyk, Florian Montano, Alessio Pieroni, Federica Viaro, Maria Luisa Zedde, Rosa Napoletano, Mario Ermani and Claudio Baracchini
    Citation: Neurological Research and Practice 2023 5:5
    Content type: Research article Published on:

  21. Ulnar mononeuropathy at the elbow is the second most frequent neuropathy in humans. Diagnosis is based on clinical and electrophysiological criteria and, more recently, also on ultrasound. Cross-sectional ult...

    Authors: José Manuel Pardal-Fernández, Inmaculada Diaz-Maroto, Tomás Segura and Carlos de Cabo
    Citation: Neurological Research and Practice 2023 5:4
    Content type: Research article Published on:

    A Letter has been published.

  22. Echocardiography is highly relevant in patients with ischemic stroke or TIA. Utilization of routine echocardiographic examinations [transthoracic (TTE) or transesophageal (TEE)] on stroke units remains however...

    Authors: Timolaos Rizos, Ekkehart Jenetzky, Darius Günther Nabavi, Karl Georg Haeusler, Rolf Wachter, Martin Ossenbrink, Peter Arthur Ringleb and Otto Busse
    Citation: Neurological Research and Practice 2023 5:3
    Content type: Research Article Published on:

    The Correction to this article has been published in Neurological Research and Practice 2023 5:16

  23. The aim of this study was to investigate the prognostic role of hematoma characteristics and hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (ICH).

    Authors: Renzo Manara, Ludovica De Rosa, Francesca Vodret, Caterina Kulyk, Renato Pennella, Eleonora Contrino, Giacomo Cester, Francesco Causin, Alessio Pieroni, Federica Viaro, Maria Luisa Zedde, Rosario Pascarella, Rosa Napoletano and Claudio Baracchini
    Citation: Neurological Research and Practice 2023 5:2
    Content type: Research Article Published on:

  24. We review key design elements of positive randomized controlled trials (RCTs) in acute ischemic stroke (AIS) treatment and summarize their main characteristics.

    Authors: L. Yperzeele, A. Shoamanesh, Y. V. Venugopalan, S. Chapman, M. V. Mazya, M. Charalambous, V. Caso, W. Hacke, P. M. Bath and I. Koltsov
    Citation: Neurological Research and Practice 2023 5:1
    Content type: Review Published on:

  25. The medical care of patients with myositis is a great challenge in clinical practice. This is due to the rarity of these disease, the complexity of diagnosis and management as well as the lack of systematic an...

    Authors: Marc Pawlitzki, Laura Acar, Lars Masanneck, Alice Willison, Liesa Regner-Nelke, Christopher Nelke, Helmut L’hoest, Ursula Marschall, Jens Schmidt, Sven G. Meuth and Tobias Ruck
    Citation: Neurological Research and Practice 2022 4:62
    Content type: Research Article Published on:

  26. Safety and efficacy data on intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) in case of known left ventricular thrombus (LVT) are lacking. We present the case of a 35-year-old male with disabling...

    Authors: Sofia Kitmeridou, Dimitrios Tsiptsios, Dimos Tsalkidis, Evlampia A. Psatha, Ioannis Iliopoulos, Nikolaos Aggelousis and Konstantinos Vadikolias
    Citation: Neurological Research and Practice 2022 4:61
    Content type: Letter to the editor Published on:

    The Letter to the editor to this article has been published in Neurological Research and Practice 2023 5:10

  27. The ALS Functional Rating Scale in its revised version (ALSFRS-R) is a disease-specific severity score that reflects motor impairment and functional deterioration in people with amyotrophic lateral sclerosis (...

    Authors: André Maier, Matthias Boentert, Peter Reilich, Simon Witzel, Susanne Petri, Julian Großkreutz, Moritz Metelmann, Paul Lingor, Isabell Cordts, Johannes Dorst, Daniel Zeller, René Günther, Tim Hagenacker, Torsten Grehl, Susanne Spittel, Joachim Schuster…
    Citation: Neurological Research and Practice 2022 4:60
    Content type: Research Article Published on:

  28. Post-stroke depression (PSD) is an important and frequent non-motor complication after a stroke. As valid prediction of PSD occurrence is still not possible, the unselective use of preventive therapy in stroke...

    Authors: Daniel Richter, Andreas Ebert, Lisa Mazul-Wach, Quirin Ruland, Jeyanthan Charles-James, Ralf Gold, Georgios Tsivgoulis, Georg Juckel and Christos Krogias
    Citation: Neurological Research and Practice 2022 4:59
    Content type: Clinical Trial Protocol Published on:

  29. Patients with a left (LHS) or right hemispheric stroke (RHS) differ in terms of clinical symptoms due to lateralization of specific cortical functions. Studies on functional outcome after stroke and endovascul...

    Authors: Milani Deb-Chatterji, Fabian Flottmann, Lukas Meyer, Caspar Brekenfeld, Jens Fiehler, Christian Gerloff and Götz Thomalla
    Citation: Neurological Research and Practice 2022 4:58
    Content type: Research article Published on:

  31. Misdiagnosis of seizure-like events (SLE) in emergency situations is common. Here, we evaluate whether a single, video-based lesson highlighting distinguishing semiological features can improve the diagnostic ...

    Authors: Wenke Grönheit, Vanessa Behrens, Tatjana Liakina, Christoph Kellinghaus, Soheyl Noachtar, Stoyan Popkirov, Tim Wehner, Eva Brammen and Jörg Wellmer
    Citation: Neurological Research and Practice 2022 4:56
    Content type: Research article Published on:

  32. Therapeutic options targeting inflammation in multiple sclerosis (MS) have evolved rapidly for relapsing–remitting MS, whereas few therapies are available for progressive forms of MS, in particular secondary p...

    Authors: Liesa Regner-Nelke, Marc Pawlitzki, Alice Willison, Leoni Rolfes, Sinem-Hilal Oezalp, Christopher Nelke, Tristan Kölsche, Melanie Korsen, Matthias Grothe, Sergiu Groppa, Felix Luessi, Sinah Engel, Gereon Nelles, Eckhard Bonmann, Holger Roick, Anke Friedrich…
    Citation: Neurological Research and Practice 2022 4:55
    Content type: Research article Published on:

  33. Seizure Related 6 Homolog Like 2 (SEZ6L2) protein has been shown to have implications in neuronal and especially motor function development. In oncology, overexpression of SEZ6L2 serves as a negative prognosti...

    Authors: Annika Kather, Florian Holtbernd, Robert Brunkhorst, Dimah Hasan, Robert Markewitz, Klaus-Peter Wandinger, Martin Wiesmann, Jörg B. Schulz and Simone C. Tauber
    Citation: Neurological Research and Practice 2022 4:54
    Content type: Review Published on:

  34. Recent studies have indicated that long-term neurological sequelae after COVID-19 are not accompanied by an increase of canonical biomarkers of central nervous system injury in blood, but subgroup stratificati...

    Authors: Laura de Boni, Alexandru Odainic, Natalie Gancarczyk, Luisa Kaluza, Christian P. Strassburg, Xenia A. K. Kersting, Joseph M. Johnson, Ullrich Wüllner, Susanne V. Schmidt, Jacob Nattermann and Gabor C. Petzold
    Citation: Neurological Research and Practice 2022 4:53
    Content type: Letter to the editor Published on:

  35. In the treatment of status epilepticus less is known about the influence of comorbidities on the safety profile of anticonvulsive drugs. Especially patients with diabetes mellitus may be predisposed to certain...

    Authors: Annekatrin Müller, Judith von Hofen-Hohloch, Carolin Awissus, Jens Przybilla, Achmed Mrestani and Joseph Classen
    Citation: Neurological Research and Practice 2022 4:52
    Content type: Research article Published on:

  36. Slow orthostatic tremor is an extremely rare movement disorder with relatively low-frequency tremor (< 13 Hz) in the legs and trunk, which is evoked by standing. There is still much controversy regarding its p...

    Authors: N. Ahmad Aziz, Marcus Grobe-Einsler and Oliver Kaut
    Citation: Neurological Research and Practice 2022 4:51
    Content type: Letter to the editor Published on:

  37. Although there are well known sex differences in older patients with ischemic stroke receiving acute reperfusion treatments, there is paucity of data in younger patients.

    Authors: Ralph Weber, Evgenia Winezki, Aristeidis H. Katsanos, Melissa Cueillette, Karim Hajjar, Elif Yamac, Roland Veltkamp and Rene Chapot
    Citation: Neurological Research and Practice 2022 4:50
    Content type: Research article Published on:

  38. We sought to determine the utility of PET-MRI in diagnosing Idiopathic Inflammatory Myositis (IIM), and look for association between FDG uptake and clinical, pathological and laboratory parameters.

    Authors: Manu Santhappan Girija, Ravindu Tiwari, Seena Vengalil, Saraswati Nashi, Veeramani Preethish-Kumar, Kiran Polavarapu, Karthik Kulanthaivelu, Arpana Arbind, Mainak Bardhan, Akshata Huddar, Gopikrishnan Unnikrishnan, Valasani Ravi Kiran, Tanushree Chawla, Bevinahalli Nandeesh, Chandana Nagaraj and Atchayaram Nalini
    Citation: Neurological Research and Practice 2022 4:49
    Content type: Research article Published on:

  39. Cervical dystonia (CD) is characterized by involuntary contractions of the cervical muscles. Data on long-term effectiveness of deep brain stimulation (DBS) are rare. The aim of this study was to evaluate the ...

    Authors: Clemens Jacksch, Kirsten E. Zeuner, Ann-Kristin Helmers, Karsten Witt, Günther Deuschl and Steffen Paschen
    Citation: Neurological Research and Practice 2022 4:48
    Content type: Research article Published on:

  40. Several non-motor symptoms are present in Parkinson's disease (PD), including increasing prevalence rates of cognitive impairment during disease progression. Due to its multifaceted nature, PD management invol...

    Authors: Jennifer Michels, Cornelius J. Werner, Beate Schumann-Werner, Jörg B. Schulz, Ana S. Costa and Kathrin Reetz
    Citation: Neurological Research and Practice 2022 4:47
    Content type: Research article Published on:

  41. This study aims to characterize the impact of apraxia and visuospatial neglect on stroke patients’ cognitive and functional outcomes during early rehabilitation. Prior work implies an unfavorable effect of vis...

    Authors: S. Latarnik, J. Stahl, S. Vossel, C. Grefkes, G. R. Fink and P. H. Weiss
    Citation: Neurological Research and Practice 2022 4:46
    Content type: Research article Published on:

  42. To mitigate the potential consequences of the coronavirus disease 2019 (COVID-19) pandemic on public life, the German Federal Government and Ministry of Health enacted a strict lockdown protocol on March 16, 2...

    Authors: Kimberly Körbel, Felix Rosenow, Margarita Maltseva, Heiko Müller, Juliane Schulz, Panagiota-Eleni Tsalouchidou, Lisa Langenbruch, Stjepana Kovac, Katja Menzler, Mario Hamacher, Felix von Podewils, Laurent M. Willems, Catrin Mann and Adam Strzelczyk
    Citation: Neurological Research and Practice 2022 4:44
    Content type: Research article Published on:

  43. Autoimmune-mediated neural inflammation can affect both the central and the peripheral nervous system. Recently, antibodies against the peripheral membrane protein flotillin have been described in patients wit...

    Authors: Tobias A. Wagner-Altendorf, Klaus-Peter Wandinger, Robert Markewitz, Anna Antufjew, Tobias Boppel and Thomas F. Münte
    Citation: Neurological Research and Practice 2022 4:43
    Content type: Letter to the editor Published on:

  44. Oral anticoagulation (OAC) is the mainstay of secondary prevention in ischemic stroke patients with atrial fibrillation (AF). However, in AF patients with large vessel occlusion stroke treated by endovascular ...

    Authors: Johannes M. Weller, Franziska Dorn, Julius N. Meissner, Sebastian Stösser, Niklas M. Beckonert, Julia Nordsiek, Christine Kindler, Christoph Riegler, Fee Keil, Gabor C. Petzold and Felix J. Bode
    Citation: Neurological Research and Practice 2022 4:42
    Content type: Research article Published on:

  45. Brain tumor related epilepsy (BTRE) is a common complication of cerebral tumors and its incidence is highly dependent on the type of tumor, ranging from 10–15% in brain metastases to > 80% in low grade gliomas...

    Authors: Sabine Seidel, Tim Wehner, Dorothea Miller, Jörg Wellmer, Uwe Schlegel and Wenke Grönheit
    Citation: Neurological Research and Practice 2022 4:45
    Content type: Review Published on:

  46. With the optimization of medical care structures and the rapid progress in the development of new therapeutic methods, an increase in life expectancy is observed in patients with neuromuscular diseases. This l...

    Authors: Michael Fleischer, Bayram Coskun, Benjamin Stolte, Adela Della-Marina, Heike Kölbel, Hildegard Lax, Michael Nonnemacher, Christoph Kleinschnitz, Ulrike Schara-Schmidt and Tim Hagenacker
    Citation: Neurological Research and Practice 2022 4:41
    Content type: Research article Published on:

  47. Chronic headache due to the overuse of medication for the treatment of migraine attacks has a prevalence of 0.5–2.0%. This guideline provides guidance for the management of medication overuse (MO) and medicati...

    Authors: Hans-Christoph Diener, Peter Kropp, Thomas Dresler, Stefan Evers, Stefanie Förderreuther, Charly Gaul, Dagny Holle-Lee, Arne May, Uwe Niederberger, Sabrina Moll, Christoph Schankin and Christian Lampl
    Citation: Neurological Research and Practice 2022 4:37
    Content type: Guidelines Published on:

  48. Hypoglycemia in patients with diabetes mellitus, particularly type 1 can mimic acute ischemic stroke by causing focal neurological deficits. In acute ischemic stroke, the interpretation of emergency imaging in...

    Authors: Jennifer Sartor-Pfeiffer, Mirjam Lingel, Maria-Ioanna Stefanou, Tobias Lindig, Benjamin Bender, Sven Poli, Ulf Ziemann, Andreas Fritsche, Katharina Feil and Annerose Mengel
    Citation: Neurological Research and Practice 2022 4:36
    Content type: Letter to the editor Published on:

  49. Super-refractory status epilepticus (SRSE) represents the culmination of refractory status epilepticus (RSE) and carries a significant risk of poor neurological outcome and high mortality. RSE is not defined p...

    Authors: Michael P Malter and Janina Neuneier
    Citation: Neurological Research and Practice 2022 4:35
    Content type: Standard operating procedure Published on:

  50. Adenylyl cyclase 5 (ADCY5) related dyskinesia is a rare disorder characterized by early-onset paroxysmal choreoathetosis, dystonia, myoclonus, or a combination of the above, which primarily involved the limbs,...

    Authors: Shih-Ying Chen, Chen-Jui Ho, Yan-Ting Lu, Chih-Hsiang Lin and Meng-Han Tsai
    Citation: Neurological Research and Practice 2022 4:39
    Content type: Letter to the editor Published on:
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